Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits.
Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits.
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DOI：
10.1523/jneurosci.1593-10.2010
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发表时间：
2010-08-25
期刊：
影响因子：
--
通讯作者：
Lipton SA
中科院分区：
文献类型：
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作者：
Piña-Crespo JC;Talantova M;Micu I;States B;Chen HS;Tu S;Nakanishi N;Tong G;Zhang D;Heinemann SF;Zamponi GW;Stys PK;Lipton SA
NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 ‘NMDA receptor’ subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.
