Cigarette Smoking Is Associated with a Lower Prevalence of Newly Diagnosed Diabetes Screened by OGTT than Non-Smoking in Chinese Men with Normal Weight.
Cigarette Smoking Is Associated with a Lower Prevalence of Newly Diagnosed Diabetes Screened by OGTT than Non-Smoking in Chinese Men with Normal Weight.
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DOI：
10.1371/journal.pone.0149234
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
China National Diabetes Metabolic Disorders Study Group
中科院分区：
文献类型：
--
作者：
Hou X;Qiu J;Chen P;Lu J;Ma X;Lu J;Weng J;Ji L;Shan Z;Liu J;Tian H;Ji Q;Zhu D;Ge J;Lin L;Chen L;Guo X;Zhao Z;Li Q;Zhou Z;Yang W;Jia W;China National Diabetes Metabolic Disorders Study Group
关于吸烟与糖尿病之间的关系，不同的研究得出了相互矛盾的结果，并且缺乏基于全国样本的中国男性这一问题的详细分析。我们通过基于人群的病例对照分析探讨了中国男性吸烟与新诊断糖尿病 (NDM) 之间的关联；包括 16,286 名先前未诊断出糖尿病的男性参与者。使用口服葡萄糖耐量试验诊断前驱糖尿病和 NDM。该队列包括 6,913 名非吸烟者 (42.4%)、1,479 名戒烟者 (9.1%) 和 7,894 名当前吸烟者 (48.5%)。目前吸烟者在空腹和 120 分钟时的年龄调整葡萄糖浓度 (mmol/L) 显着低于不吸烟者（分别为 5.25 vs. 5.30、6.46 vs. 6.55，均 P < 0.01）。调整人口和行为变量（年龄、地区、饮酒状况、体力活动、教育程度和糖尿病家族史）后，逻辑回归显示，正常体重男性（BMI < 25 kg/m2：调整优势比 [AOR] = 0.75，P = 0.007；腰围 < 90 cm：AOR = 0.71，P = 0.001）和中国南方男性吸烟与 NDM 之间存在显着负相关。 （AOR = 0.75，P = 0.009），但不适用于超重/肥胖的男性、中心性肥胖的男性或居住在中国北方的男性。与不吸烟者相比，目前吸烟者发生中心性肥胖或血压升高的可能性较小（AOR：0.82和0.74，均P < 0.05），而重度吸烟者（≥20包年）在正常体重的男性中发生TG升高的可能性较小（AOR = 0.84，P = 0.012）。无论是在正常体重的男性还是超重/肥胖的男性中，戒烟与代谢紊乱之间都没有显着关联。总之，在体重指数较低/腰围较小的中国男性中，吸烟者患 NDM 的可能性低于不吸烟者。
Different studies have produced conflicting results regarding the association between smoking and diabetes mellitus, and detailed analysis of this issue in Chinese males based on nationwide samples is lacking. We explored the association between cigarette smoking and newly-diagnosed diabetes mellitus (NDM) in Chinese males using a population-based case-control analysis; 16,286 male participants without previously diagnosed diabetes were included. Prediabetes and NDM were diagnosed using the oral glucose tolerance test. The cohort included 6,913 non-smokers (42.4%), 1,479 ex-smokers (9.1%) and 7,894 current smokers (48.5%). Age-adjusted glucose concentrations (mmol/L) were significantly lower at fasting and 120 min in current smokers than non-smokers (5.25 vs. 5.30, 6.46 vs. 6.55, respectively, both P < 0.01). After adjustment for demographic and behavioral variables (age, region, alcohol consumption status, physical activity, education, and family history of diabetes), logistic regression revealed significant negative associations between smoking and NDM in males of a normal weight (BMI < 25 kg/m2: adjusted odds ratio [AOR] = 0.75, P = 0.007; waist circumference < 90 cm: AOR = 0.71, P = 0.001) and males living in southern China (AOR = 0.75, P = 0.009), but not in males who were overweight/obese, males with central obesity, or males living in northern China. Compared to non-smokers, current smokers were less likely to be centrally obese or have elevated BP (AOR: 0.82 and 0.74, both P < 0.05), and heavy smokers (≥ 20 pack-years) were less likely to have elevated TG (AOR = 0.84, P = 0.012) among males of a normal weight. There were no significant associations between quitting smoking and metabolic disorders either among males of a normal weight or males who were overweight/obese. In conclusion, smokers have a lower likelihood of NDM than non-smokers among Chinese males with a lower BMI/smaller waist.