Association between hemorrhagic stroke occurrence and meteorological factors and pollutants.
Association between hemorrhagic stroke occurrence and meteorological factors and pollutants.
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DOI：
10.1186/s12883-016-0579-2
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发表时间：
2016-05-04
期刊：
影响因子：
2.6
通讯作者：
Lee YJ
中科院分区：
文献类型：
--
作者：
Han MH;Yi HJ;Ko Y;Kim YS;Lee YJ
本研究的目的是根据韩国首尔城东区气象和空气污染参数的月变化，确定脑出血和蛛网膜下腔出血是否有不同的发病模式。2004年1月1日至2014年12月31日，在韩国首尔城东区居民中登记了1，477例连续出血性卒中事件（>19岁）。作者根据气象和空气污染因素计算出血性脑卒中及其亚型发病率的相对危险度。我们还使用多变量Poisson回归模型估计相对风险（95%置信区间），以确定与脑内出血或蛛网膜下腔出血发生相关的气象因素和污染物中的潜在自变量。我们观察到脑出血与平均体温呈负相关。在多变量Poisson模型中，空气动力学直径< 10 μm的颗粒物与脑出血呈正相关（相对危险度，1.09; 95%置信区间，1.02 - 1.15; P = 0.012）。相反，臭氧与蛛网膜下腔出血的发生显著相关（相对危险度，1. 32; 95%可信区间，1. 10 - 1. 58; P = 0. 003）。我们的研究结果表明，出血性脑卒中与气象参数和污染物的关系，在类似的天气和环境条件下，在一个小的区域。在气象和污染物变量中，只有较高的颗粒物浓度与脑出血的发生独立相关，而只有臭氧与蛛网膜下腔出血的发生独立相关。这些发现表明，出血性中风与气象因素和污染物之间可能存在致病联系。
The purpose of this study is to determine whether intracerebral hemorrhage and subarachnoid hemorrhage have different incidence patterns based on monthly variations in meteorological and air pollution parameters in the Seongdong district of Seoul, South Korea. From January 1, 2004 to December 31, 2014, 1,477 consecutive hemorrhagic stroke events (>19 years old) were registered among residents of the Seongdong district, Seoul, South Korea. The authors calculated the relative risk of hemorrhagic stroke and its subtype incidence based on meteorological and air pollution factors. We also estimated relative risk with 95 % confidence intervals using a multivariate Poisson regression model to identify potential independent variables among meteorological factors and pollutants associated with either intracerebral hemorrhage or subarachnoid hemorrhage occurrence. We observed a negative correlation between intracerebral hemorrhage and mean temperature. In the multivariate Poisson model, particulate matter with an aerodynamic diameter < 10 μm showed positive correlations with intracerebral hemorrhage (relative risk, 1.09; 95 % confidence interval, 1.02 to 1.15; P = 0.012). In contrast, ozone correlated significantly with subarachnoid hemorrhage occurrence (relative risk, 1.32; 95 % confidence interval, 1.10 to 1.58; P = 0.003). Our findings show the relationship between hemorrhagic stroke and meteorological parameters and pollutants under similar weather and environmental conditions in a small area. Among meteorological and pollutant variables, only higher particulate matter concentrations correlated independently with intracerebral hemorrhage occurrence, while only ozone was independently associated with subarachnoid hemorrhage occurrence. These findings suggest the possibility that there are pathogenic associations between hemorrhagic stroke and meteorological factors and pollutants.