Chemical properties of bile acids: III. Bile acid structure and solubility in water
Chemical properties of bile acids: III. Bile acid structure and solubility in water
复制标题
胆汁酸的化学性质：III。
DOI：
10.1007/bf00649524
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发表时间：
1985
影响因子：
1.2
通讯作者：
B. Grigolo
中科院分区：
文献类型：
--
作者：
A. Fini;A. Roda;R. Fugazza;B. Grigolo
The temperature dependence of the solubilities in water at pH 3.00 of a representative series of ten cholanoic acids (bile acids) were measured over the temperature range 10 to 50°C. The solubilities ranged from 5×10−8M for 3α-hydroxy-5β-cholanoic acid (lithocholic acid) to 2×10−3M for 3α-7β-12α-trihydroxy-5β-cholanoic acid (ursocholic acid). The solubilities increased with temperature and were found to be dependent on the number, position, and orientation of the hydroxyl groups. The hydroxyl groups affect solubility both by forming hydrogen bonds with the solvent and by reducing the hydrophobic area of the steroid nucleus. The enthalpic ΔH0 and entropic ΔS0 contributions to Δμ0 associated with the dissolution process were obtained from the temperature dependence of the solubilities. A qualitative interpretation of the thermodynamic parameters in relation to bile acid structure is also presented.
影响因子：
6.5
作者：
M. Armstrong;M. Carey
通讯作者：
M. Armstrong;M. Carey
使用固定化 7 α-羟基类固醇脱氢酶进行初级胆汁酸的生物发光测量：应用于血清胆汁酸。
影响因子：
6.5
作者：
Roda,A;Kricka,LJ;DeLuca,M;Hofmann,AF
通讯作者：
Hofmann,AF
DOI：
10.1016/s0021-9258(18)32418-9
发表时间：
1983-05
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
A. Roda;A. Hofmann;K. J. Mysels
通讯作者：
A. Roda;A. Hofmann;K. J. Mysels