Anti-Mullerian hormone in serum and seminal plasma in comparison with other male fertility parameters
Anti-Mullerian hormone in serum and seminal plasma in comparison with other male fertility parameters
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DOI：
10.3109/19396368.2016.1161864
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发表时间：
2016-01-01
影响因子：
2.4
通讯作者：
Topolcan, Ondrej
中科院分区：
文献类型：
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作者：
Kucera, Radek;Ulcova-Gallova, Zdenka;Topolcan, Ondrej
抗苗勒管激素（AMH）是与女性生育能力尤其是卵巢储备最相关的因素。AMH也被用作男性生育能力的参数，因为它起源于含有产生AMH的支持细胞的精小管上皮。为了探讨AMH的产生与精子相关参数的关系，我们比较了65名健康男性和68名精液病理的不育夫妇血清和精浆中AMH的水平。我们评估了以下生育参数：精子数量（SC），顶体内酶（IAE）的存在和抗精子抗体（ASA）。根据SC小于1500万、SC小于1500万且无IAE、SC小于1500万且存在ASA、所有三个病理参数均存在，将不育男性分为四个亚组。健康组血清AMH平均水平为6.95 ng/ml，两组间差异无统计学意义。健康组精浆AMH平均水平为14.21 ng/ml。我们观察到，SC少于1500万精子组（3.29 ng/ml, p=0.0001）、SC少于1500万精子且缺乏IAE组（3.95 ng/ml, p=0.0046）和所有三个病理参数组（2.65 ng/ml, p=0.0001）的精子数量均有统计学意义的下降
Anti-Mullerian hormone (AMH) is a factor most associated with female fertility and especially with the ovarian reserve. AMH is also used as a parameter of fertility in men as it arises from the epithelium of the seminiferous tubules that contain Sertoli cells which produce the AMH. To investigate the relationship between AMH production and sperm related parameters we compared the AMH levels in serum and seminal plasma between a group of healthy males (n=65) and male patients (n=68) of infertile couples with semen pathology. We assessed the following fertility parameters: sperm count (SC), presence of intra-acrosomal enzymes (IAE), and antispermatozoal antibodies (ASA). Infertile men were divided into four subgroups according to: SC less than 15 million, SC less than 15 million and lack of IAE, SC less than 15 million and presence of ASA, presence of all three pathological parameters. The mean AMH serum level in the healthy group was 6.95 ng/ml and no significant difference was observed in serum AMH levels. The mean AMH seminal plasma level in the healthy group was 14.21 ng/ml. We observed a statistically significant decrease in the group with a SC with less than 15 million (3.29 ng/ml, p=0.0001) sperm, in the group with SC less than 15 million sperm and lack of IAE (3.95 ng/ml, p=0.0046), and in the group with all three pathological parameters (2.65 ng/ml, p=