Voxel-Based Meta-Analytical Evidence of Structural Disconnectivity in Major Depression and Bipolar Disorder
Voxel-Based Meta-Analytical Evidence of Structural Disconnectivity in Major Depression and Bipolar Disorder
复制标题
DOI：
10.1016/j.biopsych.2015.03.004
复制
发表时间：
2016-02-15
影响因子：
10.6
通讯作者：
Arnone, Danilo
中科院分区：
文献类型：
--
作者：
Wise, Toby;Radua, Joaquim;Arnone, Danilo
背景技术背景：识别重性抑郁症和双相情感障碍之间的白色微结构差异和相似性是更好地理解情感障碍的潜在脑异常和更有效治疗的必要步骤。然而，研究尚未得出有力的结论。我们在这里报告的荟萃分析的扩散张量成像研究在这些conditions.METHODS：进行了全面的文献检索到2014年，以确定研究比较分数各向异性（FA）患者和对照组之间。结果被结合起来，以确定白色物质异常的抑郁症（736例患者与668名对照组）和双相情感障碍（536例患者与489名对照组）。效应量比较和关联分析允许识别的相似性和差异之间的disorders.RESULTS：一个显着减少FA的胼胝体的特征，这两种条件的。单相和双相情感障碍之间的比较显示，双相情感障碍的左后扣带回FA下降幅度更大。采用基于道的空间统计方法的研究表明，在这些地区相比，基于体素的analysis.CONCLUSIONS：重度抑郁症和双相情感障碍的特点是异常的白色物质束的胼胝体，连接两个半球的前额叶皮层牵连在情绪调节。双相情感障碍与左后扣带回白色物质完整性降低相关，这可能导致该疾病中描述的认知障碍。与基于体素的分析相比，基于道的空间统计可能是检测这些区域中的白色物质异常的更敏感的技术。
BACKGROUND: Identification of white matter microstructure differences and similarities between major depression and bipolar disorder is a necessary step to better understand the underlying brain abnormalities in affective disorders and target more effective treatments. However, research has not yet yielded robust conclusions. We report here a meta-analysis of diffusion tensor imaging studies in these conditions.METHODS: A comprehensive literature search was conducted up to 2014 to identify studies comparing fractional anisotropy (FA) between patients and control subjects. Results were combined to identify white matter abnormalities in major depression (736 patients vs. 668 control subjects) and bipolar disorder (536 patients vs. 489 control subjects). Effect size comparison and conjunction analysis allowed identification of similarities and differences between the disorders.RESULTS: A significant decrease in FA in the genu of the corpus callosum characterized both conditions. The comparison between unipolar and bipolar disorders revealed a greater decrease in FA in the left posterior cingulum in bipolar disorder. Studies that adopted tract-based spatial statistics methodology showed more pronounced reductions in these regions compared with voxel-based analyses.CONCLUSIONS: Major depression and bipolar disorder are characterized by abnormalities in white matter tracts of the genu of the corpus callosum that connect the two hemispheres of the prefrontal cortex implicated in mood regulation. Bipolar disorder was associated with reduced white matter integrity in the left posterior cingulum, which may contribute to cognitive impairment described in this condition. Tract-based spatial statistics may be a more sensitive technique to detect white matter abnormalities in these regions compared with voxel-based analyses.