Interobserver agreement of skeletal muscle mass measurement on head and neck CT imaging at the level of the third cervical vertebra
Interobserver agreement of skeletal muscle mass measurement on head and neck CT imaging at the level of the third cervical vertebra
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DOI：
10.1007/s00405-019-05307-w
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发表时间：
2019-04-01
影响因子：
2.6
通讯作者：
de Bree, R.
中科院分区：
文献类型：
--
作者：
Bril, S. I.;Wendrich, A. W.;de Bree, R.
目的：在癌症患者中，最常在第三腰椎（L3）水平进行腹部计算机断层扫描（CT）成像评估骨骼肌质量（SMM）。腹部CT成像不是头颈部癌症（HNC）患者的常规检查。最近，发表了一种在第三颈椎（C3）水平的单个横向CT切片上评估SMM的新方法。本研究的目的是评估这种新的C3测量方法的鲁棒性interobserver agreement.Patients and the methodsPatients诊断为局部晚期头颈部鳞状细胞癌（LA-HNSCC）在我们的中心之间的2007年和2011年进行了评估。随机选择54例患者进行分析。6名观察员独立测量C3水平的横截肌肉面积（CSMA），使用预定义的书面协议作为指导。使用组内相关系数（ICC）、Bland-Altman图和Fleiss' kappa（）评估观察者之间的一致性。结果所有观察者之间在椎体选择方面的一致性非常好（Fleiss'：0.96）。所有观察者在单切片选择中基本一致（Fleiss'：0.61）。对于所有的CSMA测量，ICC都是极好的（0.763-0.969;所有p
ObjectivesSkeletal muscle mass (SMM) is most often assessed in cancer patients on abdominal computed tomography (CT) imaging at the level of the third lumbar vertebra (L3). Abdominal CT imaging is not routinely performed in head and neck cancer (HNC) patients. Recently, a novel method to assess SMM on a single transversal CT slice at the level of the third cervical vertebra (C3) was published. The objective of this study was to assess the robustness of this novel C3 measurement method in terms of interobserver agreement.Patients and methodsPatients diagnosed with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) at our center between 2007 and 2011 were evaluated. Fifty-four patients with were randomly selected for analysis. Six observers independently measured the cross-sectional muscle area (CSMA) at the level of C3 using a predefined, written protocol as instruction. Interobserver agreement was assessed using intraclass correlation coefficients (ICCs), a Bland-Altman plot and Fleiss' kappa ().ResultsThe agreement in vertebra selection between all observers was excellent (Fleiss' : 0.96). There was a substantial agreement between all observers in single slice selection (Fleiss' : 0.61). For all CSMA measurements, ICCs were excellent (0.763-0.969; all p