Disseminating tumor cells and their interactions with leukocytes visualized in the brain.
Disseminating tumor cells and their interactions with leukocytes visualized in the brain.
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DOI：
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发表时间：
1992-02
期刊：
影响因子：
11.2
通讯作者：
L. Lampson;P. Wen;V. Roman;J. Morris;J. Sarid
中科院分区：
文献类型：
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作者：
L. Lampson;P. Wen;V. Roman;J. Morris;J. Sarid
脑肿瘤越来越普遍。最近的进展将注意力集中在无法成像或消除的单个播散性肿瘤细胞上。免疫系统的细胞可能非常适合攻击单个肿瘤细胞，但需要更基本的理解。我们描述了一种大鼠模型，使用lacZ报告基因，允许识别个体肿瘤细胞，和肿瘤-白细胞在体内的相互作用。该模型证明了肿瘤可以广泛传播，而没有继发性肿瘤发生或募集非肿瘤细胞。表明白细胞可进入播散性肿瘤。在其众多应用中，这项工作为开发针对单个脑肿瘤细胞的细胞介导的免疫疗法奠定了基础。
Brain tumors are increasingly prevalent. Recent advances focus attention on individual, disseminated tumor cells that cannot be imaged or eliminated. Cells of the immune system may be ideally suited to attack individual tumor cells, but more basic understanding is needed. We describe a rat model, using the lacZ reporter gene, that allows identification of individual tumor cells, and tumor-leukocyte interactions in vivo. The model demonstrates how widely tumor can disseminate, without secondary tumorigenesis or recruitment of nonneoplastic cells. It demonstrates that leukocytes have access to disseminating tumor. Among its many applications, this work lays a foundation for developing cell-mediated immunotherapy against individual brain tumor cells.