Selective antibacterial effects of mixed ZnMgO nanoparticles.
Selective antibacterial effects of mixed ZnMgO nanoparticles.
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DOI：
10.1007/s11051-013-1595-4
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发表时间：
2013-05
影响因子：
2.5
通讯作者：
Delmas, Bernard
中科院分区：
文献类型：
--
作者：
Vidic, Jasmina;Stankic, Slavica;Haque, Francia;Ciric, Danica;Le Goffic, Ronan;Vidy, Aurore;Jupille, Jacques;Delmas, Bernard
Antibiotic resistance has impelled the research for new agents that can inhibit bacterial growth without showing cytotoxic effects on humans and other species. We describe the synthesis and physicochemical characterization of nanostructured ZnMgO whose antibacterial activity was compared to its pure nano-ZnO and nano-MgO counterparts. Among the three oxides, ZnO nanocrystals—with the length of tetrapod legs about 100 nm and the diameter about 10 nm—were found to be the most effective antibacterial agents since both Gram-positive (B. subtilis) and Gram-negative (E. coli) bacteria were completely eradicated at concentration of 1 mg/mL. MgO nanocubes (the mean cube size ~50 nm) only partially inhibited bacterial growth, whereas ZnMgO nanoparticles (sizes corresponding to pure particles) revealed high specific antibacterial activity to Gram-positive bacteria at this concentration. Transmission electron microscopy analysis showed that B. subtilis cells were damaged after contact with nano-ZnMgO, causing cell contents to leak out. Our preliminary toxicological study pointed out that nano-ZnO is toxic when applied to human HeLa cells, while nano-MgO and the mixed oxide did not induce any cell damage. Overall, our results suggested that nanostructured ZnMgO, may reconcile efficient antibacterial efficiency while being a safe new therapeutic for bacterial infections.
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影响因子：
2.5
作者：
Jin, Tony;He, Yiping
通讯作者：
He, Yiping
影响因子：
3.9
作者：
Huang, L;Li, DQ;Duan, X
通讯作者：
Duan, X
DOI：
10.1111/j.1744-7402.2012.02834.x
发表时间：
2013-11-01
影响因子：
2.1
作者：
Jastrzebska, Agnieszka Maria;Polis, Pawel;Kunicki, Antoni Ryszard
通讯作者：
Kunicki, Antoni Ryszard
影响因子：
19
作者：
Makhluf, S;Dror, R;Gedanken, A
通讯作者：
Gedanken, A
DOI：
10.1073/pnas.79.9.2855
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
MOODY, CS;HASSAN, HM
通讯作者：
HASSAN, HM