Topsentinols, 24-isopropyl steroids from the marine sponge Topsentia sp.
Topsentinols, 24-isopropyl steroids from the marine sponge Topsentia sp.
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DOI：
10.1021/np100374b
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发表时间：
2010-09-24
影响因子：
5.1
通讯作者：
Williams PG
中科院分区：
文献类型：
--
作者：
Dai J;Sorribas A;Yoshida WY;Kelly M;Williams PG
3个异丙基甾醇K、L和三硫酸钾(1-3)是从一个未记述的毛状藻中分离得到的。新化合物的结构通过广泛的一维和二维核磁共振实验和质谱学确定。托品醇K三硫酸盐(3)抑制天冬氨酸蛋白酶BACE1，但以一种洗涤剂依赖的方式暗示非特异性聚集。
Three isopropyl steroids, topsentinols K, L, and K trisulfate (1–3) were isolated from an undescribed species of Topsentia (Demospongiae: Halichondrida: Halichondriidae). The structures of the new compounds were determined by extensive 1D and 2D NMR experiments and mass spectrometry measurements. Topsentinol K trisulfate (3) inhibited the aspartic protease BACE1 although in a detergent-dependent manner suggestive of non-specific aggregation.