Crowding-induced organization of cytoskeletal elements: II. Dissolution of spontaneously formed filament bundles by capping proteins.
Crowding-induced organization of cytoskeletal elements: II. Dissolution of spontaneously formed filament bundles by capping proteins.
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DOI：
10.1083/jcb.126.1.169
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发表时间：
1994-07
期刊：
影响因子：
--
通讯作者：
Herzfeld J
中科院分区：
文献类型：
--
作者：
Madden TL;Herzfeld J
通过计算拥挤的解决方案中的分子包装约束，我们以前已经表明，分散体的细丝形成蛋白质和可溶性蛋白质可以是不稳定的生理浓度，这样的紧束的细丝自发形成，在没有任何辅助结合蛋白。在这里，我们认为这种现象的调制加帽蛋白质。该理论预测，通过缩短平均长丝长度，加盖简化了包装问题。因此，分散的各向同性溶液在扩大的组成范围内是稳定的。
Through calculations of molecular packing constraints in crowded solutions, we have previously shown that dispersions of filament forming proteins and soluble proteins can be unstable at physiological concentrations, such that tight bundles of filaments are formed spontaneously, in the absence of any accessory binding proteins. Here we consider the modulation of this phenomenon by capping proteins. The theory predicts that, by shortening the average filament length, capping alleviates the packing problem. As a result, the dispersed isotropic solution is stable over an expanded range of compositions.