Broadband terahertz time-domain spectroscopy of drugs-of-abuse and the use of principal component analysis
Broadband terahertz time-domain spectroscopy of drugs-of-abuse and the use of principal component analysis
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DOI：
10.1039/b817839a
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发表时间：
2009-01-01
期刊：
影响因子：
4.2
通讯作者：
Davies, A. Giles
中科院分区：
文献类型：
--
作者：
Burnett, Andrew D.;Fan, Wenhui;Davies, A. Giles
太赫兹频率时域光谱学已被用于分析含有盐酸可卡因、海洛因和摇头丸-常见的滥用药物-的各种样品。我们调查了执法机构查获的真实世界样品，以及纯滥用药物，以及在实验室中系统掺杂以模仿真实世界样品的纯滥用药物。为了探讨太赫兹光谱技术自动识别此类违禁物质的可行性，采用主成分分析法对相似化合物的光谱进行聚类分析。
Terahertz frequency time-domain spectroscopy has been used to analyse a wide range of samples containing cocaine hydrochloride, heroin and ecstasy - common drugs-of-abuse. We investigated real-world samples seized by law enforcement agencies, together with pure drugs-of-abuse, and pure drugs-of-abuse systematically adulterated in the laboratory to emulate real-world samples. In order to investigate the feasibility of automatic spectral recognition of such illicit materials by terahertz spectroscopy, principal component analysis was employed to cluster spectra of similar compounds.