A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge
A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge
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DOI：
10.1016/j.virol.2017.05.021
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发表时间：
2017-09-01
期刊：
影响因子：
3.7
通讯作者：
Hurwitz, Julia L.
中科院分区：
文献类型：
--
作者：
Russell, Charles J.;Jones, Bart G.;Hurwitz, Julia L.
人类偏肺病毒（hMPV）感染对幼儿构成严重的健康风险，特别是在早产的情况下。没有许可的疫苗存在，除了支持性医院护理外，没有标准的hMPV感染治疗。我们描述了仙台病毒（SeV）重组体的生产，该重组体携带截短的hMPV融合（F）蛋白基因（SeV-MPV-Ft）。该疫苗在棉鼠系统中诱导针对hMPV的结合和中和抗体应答以及针对hMPV攻击的保护。结果鼓励SeV-MPV-Ft的进一步开发，以预防幼儿中hMPV感染引起的发病率和死亡率。
Human metapneumovirus (hMPV) infections pose a serious health risk to young children, particularly in cases of premature birth. No licensed vaccine exists and there is no standard treatment for hMPV infections apart from supportive hospital care. We describe the production of a Sendai virus (SeV) recombinant that carries a gene for a truncated hMPV fusion (F) protein (SeV-MPV-Ft). The vaccine induces binding and neutralizing antibody responses toward hMPV and protection against challenge with hMPV in a cotton rat system. Results encourage advanced development of SeV-MPV-Ft to prevent the morbidity and mortality caused by hMPV infections in young children.