Type 2 Diabetes and Glycemic Variability: Various Parameters in Clinical Practice.
Type 2 Diabetes and Glycemic Variability: Various Parameters in Clinical Practice.
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DOI：
10.14740/jocmr3556w
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发表时间：
2018-10
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影响因子：
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通讯作者：
Sakamoto M
中科院分区：
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作者：
Sakamoto M
由于最近连续血糖监测和快速血糖监测系统等相关设备的发展，连续测量24小时至约2周的血糖水平已成为可能。这不仅使医疗专业人员而且使患者能够监测血糖变异性 (GV) 的详细信息，这在过去是不可能的。现在可以获得短期和中期 GV 的详细信息，并且在患者护理中适当评估所获得的数据非常重要。 GV 的类型在时间范围上有短期和长期之分。多项研究报告称，长期 GV 与 2 型糖尿病 (T2DM) 患者的微血管病和大血管病有关。然而，不同GV持续时间与预后的关系仍不清楚。需要进一步的临床试验来检查 GV 的机制并评估 GV 是否可以成为治疗 T2DM 患者的有价值的治疗靶点。
It has become possible to measure blood glucose levels continuously from 24 h to approximately 2 weeks due to the recent development of relevant devices such as continuous glucose monitoring and flash glucose monitoring systems. This has enabled not only medical professionals but also patients to monitor details of glycemic variability (GV) which was not possible in the past. Details of GV for both short and intermediate periods can now be obtained, and it is important in patient care to appropriately evaluate the data obtained. Types of GV in terms of time frame vary from short-term to long-term. Several studies reported that long-term GV was related to micro- and macro-angiopathies in patients with type 2 diabetes mellitus (T2DM). However, there are still unknown aspects regarding the relationships of various durations of GV with prognosis. Further clinical trials are required to examine the mechanism of GV and to evaluate whether GV can be a valuable therapeutic target in treatment of patients with T2DM.