Acquired recipient pulmonary function is better than lost donor pulmonary function in living-donor lobar lung transplantation.
Acquired recipient pulmonary function is better than lost donor pulmonary function in living-donor lobar lung transplantation.
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在活体供体肺叶移植中，获得的受者肺功能优于供体肺功能的丧失。
DOI：
10.1016/j.jtcvs.2019.06.058
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Date H.
中科院分区：
文献类型：
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作者：
Kayawake H;Chen-Yoshikawa TF;Hamaji M;Nakajima D;Ohsumi A;Aoyama A;Date H.
在标准的双侧活体供者肺叶移植（LDLLT）中，将来自2名健康供体的右下叶和左下叶植入受体体内，代替整个右肺和左肺。换句话说，在该移植程序中，总共10个叶（每个供体中5个叶）由2个供体（每个供体中4个叶）和受体（2个叶）共享。本研究旨在比较LDLLT.MethodsWe之前和之后的供体和受体之间的肺功能进行了76 LDLLT程序之间2008年6月和2017年3月。在排除12例单LDLLT和11例保留自体肺的LDLLT手术后，我们确定了38例存活>1年的双侧LDLLT接受者，并进行了常规肺功能检查。获得性受体肺功能进行了比较，失去供体肺功能在1年后LDLLT.ResultsThe的38个收件人的中位年龄为44岁（范围，8-62岁），14名男性。76名供体的中位年龄为41.5岁（范围：20-60岁）; 50名为男性。LDLLT后一年，获得的受体用力肺活量显著大于丧失的供体用力肺活量（1889.5 ± 581.3 mL vs 1073.9 ± 661.6 mL;P<0.001）。同样，在LDLLT后1年，获得的受体1秒用力呼气量显著大于丧失的供体1秒用力呼气量（1646.8 ± 483.0 mL vs 1064.2 ± 534.5 mL;P<0.001）。
ObjectiveIn standard bilateral living-donor lobar lung transplantation (LDLLT), the right and left lower lobes from 2 healthy donors are implanted in the recipient in place of whole right and left lungs. In other words, total 10 lobes (5 lobes in each donor) are shared by the 2 donors (4 lobes in each donor) and the recipient (2 lobes) in this transplant procedure. This study aimed to compare pulmonary function between donors and recipients before and after LDLLT.MethodsWe performed 76 LDLLT procedures between June 2008 and March 2017. After excluding 12 single LDLLT and 11 native–lung-sparing LDLLT procedures, we identified 38 recipients of bilateral LDLLT who survived >1 year and underwent routine pulmonary function testing. Acquired recipient pulmonary function was compared with lost donor pulmonary function at 1 year post-LDLLT.ResultsThe median age of the 38 recipients was 44 years (range, 8-62 years); 14 were men. The median age of the 76 donors was 41.5 years (range, 20-60 years); 50 were men. One year post-LDLLT, acquired recipient forced vital capacity was significantly greater than lost donor forced vital capacity (1889.5 ± 581.3 mL vs 1073.9 ± 661.6 mL;P< .001). Similarly, acquired recipient forced expiratory volume in 1 second at 1 year post-LDLLT was significantly greater than lost donor forced expiratory volume in 1 second (1646.8 ± 483.0 mL vs 1064.2 ± 534.5 mL;P< .001).ConclusionsThese results indicated that acquired recipient pulmonary function was better than lost donor pulmonary function in bilateral LDLLT.