Biomechanical Role of Bone Anisotropy Estimated on Clinical CT Scans by Image Registration
Biomechanical Role of Bone Anisotropy Estimated on Clinical CT Scans by Image Registration
复制标题
通过图像配准评估临床 CT 扫描骨各向异性的生物力学作用
DOI：
--
复制
发表时间：
2016
影响因子：
3.8
通讯作者：
P. Büchler
中科院分区：
文献类型：
--
作者：
E. Taghizadeh;M. Reyes;P. Zysset;A. Latypova;A. Terrier;P. Büchler
基于图像的建模是一种流行的方法来执行特定患者的生物力学模拟。准确的建模对于骨科应用评估种植体设计和手术计划至关重要。研究表明，骨强度可以通过骨密度和骨小梁结构来估计。然而，这些发现不能直接和完全地转移到患者特异性模型中，因为只有BMD可以从临床CT中获得。因此，本研究的目的是提出一种使用微CT图谱和图像配准技术预测骨小梁结构的方法。该方法已在生理负荷下对股骨和髌骨进行了评估。用各向同性材料预测股骨站立时的位移和极限力，误差分别为2.5%和3.7%，而用各向同性材料预测的误差分别为7.3%和6.9%。髌骨也得到了类似的结果，与各向同性模型相比，使用配准方法预测的应变导致了均方误差的改善。我们的结论是，与各向同性模型相比，单模板骨的各向异性信息的配准可以从临床图像数据集中获得更准确的患者特异性模拟。
Image-based modeling is a popular approach to perform patient-specific biomechanical simulations. Accurate modeling is critical for orthopedic application to evaluate implant design and surgical planning. It has been shown that bone strength can be estimated from the bone mineral density (BMD) and trabecular bone architecture. However, these findings cannot be directly and fully transferred to patient-specific modeling since only BMD can be derived from clinical CT. Therefore, the objective of this study was to propose a method to predict the trabecular bone structure using a µCT atlas and an image registration technique. The approach has been evaluated on femurs and patellae under physiological loading. The displacement and ultimate force for femurs loaded in stance position were predicted with an error of 2.5% and 3.7%, respectively, while predictions obtained with an isotropic material resulted in errors of 7.3% and 6.9%. Similar results were obtained for the patella, where the strain predicted using the registration approach resulted in an improved mean squared error compared to the isotropic model. We conclude that the registration of anisotropic information from of a single template bone enables more accurate patient-specific simulations from clinical image datasets than isotropic model.