Distribution and population determinants of gamma-glutamyltransferase in a random sample of Sardinian inhabitants
Distribution and population determinants of gamma-glutamyltransferase in a random sample of Sardinian inhabitants
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DOI：
10.1007/bf00144431
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发表时间：
1996-02-01
影响因子：
13.6
通讯作者：
Mascia, P
中科院分区：
文献类型：
--
作者：
Pintus, F;Mascia, P
一些决定因素的血清γ-谷氨酰转移酶（GGT）的关系进行了研究，随机抽样的撒丁岛居民的2283名男性和2520名女性，年龄在20-59岁。该研究的目的是评估环境，行为和生化因素对GGT水平的影响。雄性动物的平均值高于雌性动物，且两种性别的平均值均随年龄增长而增加。在性别特异性多元回归分析中，GGT与体重指数（BMI）、饮酒、血清总胆固醇（T-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、载脂蛋白B（ApoB）和年龄呈正相关，与男性咖啡摄入量和体力活动呈负相关，而在女性中，该酶与BMI、饮酒、年龄、T-C、ApoB、TG和吸烟。在男性中观察到的咖啡饮用和血清GGT之间的负相关表明，咖啡可能会抑制其他因素，特别是酒精使用对肝脏中GGT的诱导作用。没有生物学机制可以解释GGT与BMI，年龄或体力活动的关系。这项研究证实了GGT作为酒精使用的一个强有力的标志物的重要性，但一些变量，从生活方式到生物学特征，也是其在“正常”人群中血浆值的重要决定因素。
The relation of a number of determinants to serum gamma-glutamyltransferase (GGT)was studied in a random sample of Sardinian inhabitants of 2283 males and 2520 females aged 20-59 years. The aim of the study was to assess the influence of environmental, behavioural and biochemical factors on GGT levels. Mean values were higher in males than in females and increased with age in both sexes. In sex-specific multiple regression analysis, GGT showed a positive association with body mass index (BMI), alcohol use, total serum cholesterol (T-C), HDL cholesterol (HDL-C), triglycerides (TG), apolipoprotein B (ApoB) and age, and a negative one with coffee consumption and physical activity in males, while in females the enzyme was positively associated with BMI, alcohol use, age, T-C, ApoB, TG and cigarette smoking. The negative association between coffee drinking and serum GGT observed in males suggests that coffee may inhibit the inducing effects of other factors, particularly alcohol use, on GGT in the liver. No biological mechanism has been suggested to explain the association of GGT with BMI, age or physical activity. This study confirms the importance of GGT as a strong marker for alcohol use; but a number of variables, ranging from life-style to biological characteristics, are also important determinants of its plasma values in the 'normal' population.