Cordatols A–D, four new anti-inflammatory bis-monoterpenoids from Illigera cordata
Cordatols A–D, four new anti-inflammatory bis-monoterpenoids from Illigera cordata
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Cordatols A–D，来自 Illigera cordata 的四种新型抗炎双单萜
DOI：
10.1016/j.bioorg.2019.02.039
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发表时间：
2019
影响因子：
5.1
通讯作者：
Xiang-Zhong Huang
中科院分区：
文献类型：
--
作者：
Min Zhou;Ruiqi Zhang;Xiaoli Zeng;Shengyong Zhang;Miao Dong;Xiang-Zhong Huang
Cordatol A-D(1-4)是四个新的柠檬烯衍生的双单萜类化合物，通过异狄尔斯-阿尔德环化和单萜前体的顺序水解而合成，是从伊利格拉的地上部分分离得到的。这些结构，包括绝对构型，是通过光谱分析确定的，并通过两步生物启发的化学转化进一步证实。此外，化合物1-4具有中等的体外抗炎活性，IC50值在17.5~24.6μM之间。本研究可能为发现潜在的抗炎药提供一个新的结构模板。
Cordatols A-D (1-4), four new limonene-derived bis-monoterpenoids plausibly biosynthesized via hetero-Diels-Alder cyclization and sequential hydrolyses of their monoterpene precursors, were isolated from the aerial parts of Illigera cordata. The structures, including absolute configuration, were established by spectroscopic analysis and further confirmed by a two-steps bioinspired chemical transformation. Moreover, compounds 1-4 exhibited moderate in vitro anti-inflammatory activity with IC50 values ranging from 17.5 to 24.6 μM. This study may provide a novel structural template for potential anti-inflammatory agent discovery.