BETA-ADRENERGIC ANTAGONISTS ATTENUATE WITHDRAWAL ANXIETY IN COCAINE-DEPENDENT AND MORPHINE-DEPENDENT RATS
BETA-ADRENERGIC ANTAGONISTS ATTENUATE WITHDRAWAL ANXIETY IN COCAINE-DEPENDENT AND MORPHINE-DEPENDENT RATS
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DOI：
10.1007/bf02244345
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发表时间：
1993-11-01
影响因子：
3.4
通讯作者：
ASTONJONES, G
中科院分区：
文献类型：
--
作者：
HARRIS, GC;ASTONJONES, G
Rats were treated chronically with either cocaine (20 mg/kg/day, 14 days), morphine (incrementing doses of 10 mg/kg/day to 80 mg/kg, 11 days) or saline. During morphine or cocaine abstinence (48 h), dependent rats showed increased anxiety-like behavior in a conditioned defensive burying paradigm as evidenced by significantly shorter latencies to begin burying as well as a 4-fold increase in burying duration relative to saline-treated animals. This withdrawal-induced increase in burying behavior was blocked by pretreatment with either the beta-adrenergic antagonist propranolol (5 mg/kg) or the lipophobic selective beta(1)-antagonist, atenolol (5 mg/ kg). These results are consistent with the possibility that activation of peripheral beta(1) receptors may substantially contribute to withdrawal-induced anxiety and that beta-adrenergic antagonists could be useful in treating in cocaine and morphine dependent addicts.
