A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis
A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis
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DOI：
10.1016/s0090-8258(03)00139-2
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发表时间：
2003-06-01
影响因子：
4.7
通讯作者：
Kawarabayashi, T
中科院分区：
文献类型：
--
作者：
Tsujioka, H;Hamada, H;Kawarabayashi, T
背景资料。绒毛膜癌发生于卵巢，起源于妊娠或非妊娠。卵巢非妊娠性绒毛膜癌极为罕见，单纯型比混合型与其他生殖细胞肿瘤相比少见。如果没有基因分析，单纯的非妊娠绒毛膜癌的诊断是非常困难的。我们报告一例单纯性非妊娠绒毛膜癌，主要发生于一位19岁女性的卵巢。腹部手术后，仔细检查肿瘤发现为单纯绒毛膜癌，没有合并其他生殖细胞肿瘤。通过DNA多态性分析，确定了该基因的非生物来源。采用EMA/CO方案的多疗程化疗对该病例有效。基因分析是确定绒毛膜癌起源的有用工具。仅通过两三个合适的VNTR基因座，我们就可以区分这种肿瘤的遗传来源。(C)2003年埃尔塞维尔科学公司(美国)。版权所有。
Background. Choriocarcinoma arises in the ovary from gestational or nongestational origin. Nongestational choriocarcinoma of the ovary is extremely rare and the pure type is less frequent than the mixed type with other germ cell tumors. Diagnosis of pure nongestational choriocarcinoma is very difficult without genetic analysis.Case. We report a pure nongestational choriocarcinoma primarily arising in a 19-year-old woman's ovary. Following abdominal operative procedure, careful examination of the tumor revealed pure choriocarcinoma without combination of other germ cell tumors. We confirmed its nongestational origin by DNA polymorphism analysis. Multiple courses of chemotherapy with an EMA/CO regimen were effective for this case.Conclusion. Genetic analysis is useful tool in determining the origin of choriocarcinoma. We could distinguish the genetic origin of this tumor analyzing only two or three appropriate VNTR loci. (C) 2003 Elsevier Science (USA). All rights reserved.