Oxygen-enhanced proton imaging of the human lung using T2
Oxygen-enhanced proton imaging of the human lung using T2
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DOI：
10.1002/mrm.20448
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发表时间：
2005-05-01
影响因子：
3.3
通讯作者：
Jakob, PM
中科院分区：
文献类型：
--
作者：
Pracht, ED;Arnold, JFT;Jakob, PM
由组织/空气界面引起的磁化率梯度导致人肺中的T-2* 时间非常短。这些磁化率梯度取决于呼吸气体的磁化率，因此应该影响T-2* 弛豫。在这项工作中，定量T-2* 映射的人肺在一个屏气的技术。使用这种方法，肺T-2* 弛豫时间测定在常氧（室内空气，21%O-2）和高氧（100%O-2）条件下，以验证这一假设。室内空气和100%O-2之间的平均T-2* 差异约为10%，并且包含通风信息，因为只有通风区域由于不同的敏感度梯度而对信号变化有贡献。Magn Reson Med 53：1193-1196，2005. (c)2005 Wiley-Liss，Inc.
Magnetic susceptibility gradients caused by tissue/air interfaces lead to very short T-2* times in the human lung. These susceptibility gradients are dependent on the magnetic susceptibility of the respiratory gas and therefore should influence T-2* relaxation. In this work, a technique for quantitative T-2* mapping of the human lung during one breath hold is presented. Using this method, the lung T-2* relaxation time was measured under normoxic (room air, 21% O-2) and hyperoxic (100% O-2) conditions to verify this assumption. The mean T-2* difference between room air and 100% O-2 is about 10% and contains ventilation information, since only ventilated regions contribute to signal change due to different susceptibility gradients. Magn Reson Med 53:1193-1196, 2005. (c) 2005 Wiley-Liss, Inc.