Morphometric analysis of the developing optic nerve of the F1 heterotic mouse and its parental strains.
Morphometric analysis of the developing optic nerve of the F1 heterotic mouse and its parental strains.
复制标题
F1 杂种优势小鼠及其亲本品系发育中视神经的形态测量分析。
DOI：
10.1016/0304-3940(90)90828-w
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发表时间：
1990
影响因子：
2.5
通讯作者：
Yu,RK
中科院分区：
文献类型：
--
作者：
Bigbee,JW;Yu,DS;Yu,RK
在髓鞘形成活动期间，DBA/2J （D2）和C57BL/6J （B6）亲本系F1杂交小鼠的中枢神经系统显示髓鞘特异性标志物水平高于任何亲本。这种所谓的髓鞘增生归因于杂种优势或杂种优势。视神经形态学比较显示，F1与亲本系视神经具有较大的髓鞘轴突和较少的前髓鞘轴突。这些观察结果表明，与亲本菌株相比，F1杂交株表现出早发性和髓鞘形成速度加快。
During the period of active myelination, the CNS of the F1 hybrid mouse, derived from DBA/2J (D2) and C57BL/6J (B6) parental strains, displays levels of myelin-specific markers which are greater than in either parent. This so-called hypermyelination has been attributed to hybrid vigor or heterosis. Morphometric comparison of the optic nerves of F1 and parental strains revealed that the F1 contains larger myelinated axons and fewer premyelinated axons. These observations suggest that, compared with its parental strains, the F1 hybrid shows an early onset and accelerated rate of myelination.