How much should we eat? The association between energy intake and mortality in a 36-year follow-up study of Japanese-American men.
How much should we eat? The association between energy intake and mortality in a 36-year follow-up study of Japanese-American men.
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我们应该吃多少？
DOI：
10.1093/gerona/59.8.b789
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Curb,JDavid
中科院分区：
文献类型：
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作者：
Willcox,BradleyJ;Yano,Katsuhiko;Chen,Randi;Willcox,DCraig;Rodriguez,BeatrizL;Masaki,KamalH;Donlon,Timothy;Tanaka,Brandi;Curb,JDavid
在许多物种中，能量限制延长了寿命，降低了与年龄相关的疾病的死亡率，但对人类的影响尚不清楚。我们在一项针对日裔美国男性的大型流行病学研究中，前瞻性地研究了这种关系。我们对1915名健康的非吸烟者进行了长达36年的跟踪调查，研究开始时年龄在45-68岁。在基线时记录24小时的饮食回忆，并对全因死亡率进行随访。在调整了年龄和其他混杂因素后，能量摄入量的后五分之一有降低死亡率的趋势，这表明摄入量低于组平均值15%的男性全因死亡的风险最低。当摄入量低于组平均值的50%时，死亡率增加。因此，我们观察了人类低能量摄入量和降低全因死亡风险之间的趋势，直到能量摄入量降至不到组平均值的一半，这与之前在其他物种上的发现一致。
Energy restriction extends life span and lowers mortality from age-related diseases in many species, but the effects in humans are unknown. We prospectively examined this relationship in a large epidemiological study of Japanese-American men. We followed 1915 healthy nonsmokers, aged 45–68 years at study onset, for 36 years. Twenty-four-hour recall of diet was recorded at baseline, and follow-up was for all-cause mortality. After adjustment for age and other confounders, there was a trend toward lower mortality in the second quintile of energy intake, suggesting that men who consumed 15% below the group mean were at the lowest risk for all-cause mortality. Increased mortality was seen with intakes below 50% of group mean. Thus, we observed trends between low energy intake and reduced risk for all-cause mortality in humans until energy intake fell to less than half the group mean, consistent with previous findings in other species.