Epidemiology of mixed Schistosoma mansoni and Schistosoma haematobium infections in northern Senegal
Epidemiology of mixed Schistosoma mansoni and Schistosoma haematobium infections in northern Senegal
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DOI：
10.1016/j.ijpara.2012.02.002
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发表时间：
2012-03-01
影响因子：
4
通讯作者：
Polman, Katja
中科院分区：
文献类型：
--
作者：
Meurs, Lynn;Mbow, Moustapha;Polman, Katja
由于非洲曼氏血吸虫病和嗜血血吸虫病流行区大量重叠，许多人面临合并感染的风险，对血吸虫病的发病率和控制可能产生不利影响。然而，迄今为止，关于血吸虫混合感染的分布和决定因素的研究很少。我们在塞内加尔北方的两个社区进行了横断面调查（n = 857），以进一步了解混合感染和异位卵消除的流行病学。S的总体流行率。mansoni和S.血吸虫感染率分别为61%和50%。在受感染的受试者中，53%有混合感染，8%表现出异位卵消除。混合感染的风险因素-即性别、居住社区和年龄-与血吸虫病流行地区的一般情况并无不同。与整体S相似。mansoni和S.在血吸虫感染方面，与年龄相关的混合感染模式显示血吸虫病的特征性凸形曲线，儿童迅速增加，青少年达到高峰，成年人下降。然而，从更详细的数据来看，S。血吸虫感染的流行率和强度似乎比S.曼森氏感染，导致混合感染减少，单一感染相对增加。随着年龄的增长，曼森感染。混合感染者的感染强度高于混合感染者。mansoni和S.单次感染者，尤其是异位虫卵清除者，感染率明显高于单次感染者（P < 0.05）。混合感染的高感染强度，以及年龄相关的感染模式之间的差异，S。mansoni和S.血吸虫病的流行病学和控制可能会产生相当大的影响，值得进一步研究血吸虫病在共同流行地区感染的潜在机制。(C)2012年澳大利亚寄生虫学会由爱思唯尔有限公司出版。保留所有权利。
Due to the large overlap of Schistosoma mansoni- and Schistosoma haematobium-endemic regions in Africa, many people are at risk of co-infection, with potential adverse effects on schistosomiasis morbidity and control. Nonetheless, studies on the distribution and determinants of mixed Schistosoma infections have to date been rare. We conducted a cross-sectional survey in two communities in northern Senegal (n = 857) to obtain further insight into the epidemiology of mixed infections and ectopic egg elimination. Overall prevalences of S. mansoni and S. haematobium infection were 61% and 50%, respectively, in these communities. Among infected subjects, 53% had mixed infections and 8% demonstrated ectopic egg elimination. Risk factors for mixed infection - i.e. gender, community of residence and age - were not different from what is generally seen in Schistosoma-endemic areas. Similar to overall S. mansoni and S. haematobium infections, age-related patterns of mixed infections showed the characteristic convex-shaped curve for schistosomiasis, with a rapid increase in children, a peak in adolescents and a decline in adults. Looking at the data in more detail however, the decline in overall S. haematobium infection prevalences and intensities appeared to be steeper than for S. mansoni, resulting in a decrease in mixed infections and a relative increase in singles. mansoni infections with age. Moreover, individuals with mixed infections had higher infection intensities of both S. mansoni and S. haematobium than those with single infections, especially those with ectopic egg elimination (P < 0.05). High infection intensities in mixed infections, as well as age-related differences in infection patterns between S. mansoni and S. haematobium, may influence disease epidemiology and control considerably, and merit further studies into the underlying mechanisms of Schistosoma infections in co-endemic areas. (C) 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.