DRUG DIFFUSION WITHIN THE BRAIN
DRUG DIFFUSION WITHIN THE BRAIN
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DOI：
10.1111/j.1749-6632.1988.tb51416.x
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发表时间：
1988-06-01
影响因子：
5.2
通讯作者：
KAYE, T
中科院分区：
文献类型：
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作者：
FENSTERMACHER, J;KAYE, T
这项研究的主要假设是，不同大脑区域的毛细血管床结构和功能存在差异。发现了室周器官和非 CVO 毛细血管床之间的三个一般差异。首先，CVO 毛细血管中 AIB 的 PS 产物比非 CVO（血脑屏障）毛细血管中的 PS 产物高出约 300 倍。其次，CVO 毛细血管中内皮细胞开窗的频率比非 CVO 毛细血管中的要高得多，并且开窗可能是内皮细胞的结构修饰，允许溶质（例如 AIB）易于通过。第三，BBB毛细血管中线粒体的频率高于CVO毛细血管； BBB毛细血管的这种高代谢潜力可能部分与血浆和脑间质液之间各种溶质的“载体介导”运输有关。还观察到所有（即 CVO 和非 CVO）脑结构之间毛细血管床的差异。这些差异包括：血流速率、白蛋白平均通过时间、毛细血管体积和表面积、灌注微血管血量、灌注毛细血管的表观百分比、AIB 的 PS 产品以及囊泡轮廓内皮内的频率。
The major hypothesis of this study is that there are differences among brain areas in capillary bed structure and function. Three general differences between circumventricular organ and non-CVO capillary beds were found. First, the PS products for AIB were about 300 times greater in CVO capillaries than in non-CVO (blood-brain barrier) capillaries. Second, the frequency of endothelial cell fenestrations was much greater in CVO capillaries than in non-CVO capillaries and the fenestrae may be structural modifications of endothelial cells that permit ready passage of solutes such as AIB. Third, the frequency of mitochondria was greater in BBB capillaries than in CVO capillaries; this high metabolic potential of BBB capillaries may be associated, in part, with" carrier-mediated" transport of various solutes between plasma and cerebral interstitial fluid. Capillary bed differences among all (ie, both CVO and non-CVO) brain structures were also observed. Among these differences are: rate of blood flow, mean transit time of albumin, capillary volume and surface area, perfused microvessel blood volume, apparent percentage of perfused capillaries, PS products for AIB, and frequency within the endothelium of vesicular profiles.