Reduced Order Models for Transstenotic Pressure Drop in the Coronary Arteries
Reduced Order Models for Transstenotic Pressure Drop in the Coronary Arteries
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DOI：
10.1115/1.4042184
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发表时间：
2019-03-01
影响因子：
1.7
通讯作者：
Shadden, Shawn C.
中科院分区：
文献类型：
--
作者：
Mirramezani, Mehran;Diamond, Scott L.;Shadden, Shawn C.
介绍了冠状动脉跨狭窄压降降阶模型的功效。冠状动脉疾病是全世界死亡的主要原因，冠状动脉压降的计算已成为评估冠状动脉狭窄功能意义的标准。综合模型通常采用三维 (3D) 计算流体动力学 (CFD) 来模拟冠状动脉血流，以便计算动脉狭窄处的跨狭窄压降。在本研究中，我们评估了不同流体动力学模型计算跨狭窄压降的能力。模型范围从代数公式到一维 (1D)、二维 (2D) 和 3D 与时间相关的 CFD 模拟。尽管文献中已经提出了几种代数压降公式，但人们发现这些模型的预测表现出很大的变化。尽管如此，我们还是证明了一个代数公式，可以对狭窄严重程度、形态、位置和流速的各种变化提供与 3D CFD 结果一致的预测。研究发现，粘性耗散和血流分离的计算对于跨狭窄冠状动脉血流动力学的精确降阶建模有重要贡献。
The efficacy of reduced order modeling for transstenotic pressure drop in the coronary arteries is presented. Coronary artery disease is a leading cause of death worldwide and the computation of pressure drop in the coronary arteries has become a standard for evaluating the functional significance of a coronary stenosis. Comprehensive models typically employ three-dimensional (3D) computational fluid dynamics (CFD) to simulate coronary blood flow in order to compute transstenotic pressure drop at the arterial stenosis. In this study, we evaluate the capability of different hydrodynamic models to compute transstenotic pressure drop. Models range from algebraic formulae to one-dimensional (1D), two-dimensional (2D), and 3D time-dependent CFD simulations. Although several algebraic pressure-drop formulae have been proposed in the literature, these models were found to exhibit wide variation in predictions. Nonetheless, we demonstrate an algebraic formula that provides consistent predictions with 3D CFD results for various changes in stenosis severity, morphology, location, and flow rate. The accounting of viscous dissipation and flow separation were found to be significant contributions to accurate reduce order modeling of transstenotic coronary hemodynamics.