Viral load and heterosexual transmission of human immunodeficiency virus type 1
Viral load and heterosexual transmission of human immunodeficiency virus type 1
复制标题
DOI：
10.1056/nejm200003303421303
复制
发表时间：
2000-03-30
影响因子：
158.5
通讯作者：
Gray, RH
中科院分区：
文献类型：
--
作者：
Quinn, TC;Wawer, MJ;Gray, RH
背景和方法：我们研究了病毒载量与其他危险因素对 1 型人类免疫缺陷病毒 (HIV-1) 异性传播的影响。在一项针对乌干达农村地区 15,127 人的社区研究中，我们确定了 415 对夫妇，其中一方为 HIV-1 阳性，另一方最初为 HIV-1 阴性，并对他们进行了长达 30 个月的前瞻性跟踪。研究人员对最初血清阴性伴侣中每 100 人年的 HIV-1 感染率与行为和生物学变量的关系进行了检查。结果：228 对夫妇中，男性伴侣为 HIV-1 阳性，187 对夫妇中，女性伴侣为 HIV-1 阳性。 415 名最初 HIV-1 阴性的伴侣中有 90 名发生了血清转化（发生率：每 100 人年 11.8 人）。男性向女性的传播率与女性向男性的传播率没有显着差异（每 100 人年 12.0 人，每 100 人年 11.6 人）。 15 至 19 岁伴侣中血清转化的发生率最高（每 100 人年 15.3 例）。 137 名未受割礼的男性伴侣中，发病率为每 100 人年 16.7 例，而 50 名受过包皮环切的男性伴侣中没有血清转化（P
Background and Methods: We examined the influence of viral load in relation to other risk factors for the heterosexual transmission of human immunodeficiency virus type 1 (HIV-1). In a community-based study of 15,127 persons in a rural district of Uganda, we identified 415 couples in which one partner was HIV-1-positive and one was initially HIV-1-negative and followed them prospectively for up to 30 months. The incidence of HIV-1 infection per 100 person-years among the initially seronegative partners was examined in relation to behavioral and biologic variables.Results: The male partner was HIV-1-positive in 228 couples, and the female partner was HIV-1-positive in 187 couples. Ninety of the 415 initially HIV-1-negative partners seroconverted (incidence, 11.8 per 100 person-years). The rate of male-to-female transmission was not significantly different from the rate of female-to-male transmission (12.0 per 100 person-years vs. 11.6 per 100 person-years). The incidence of seroconversion was highest among the partners who were 15 to 19 years of age (15.3 per 100 person-years). The incidence was 16.7 per 100 person-years among 137 uncircumcised male partners, whereas there were no seroconversions among the 50 circumcised male partners (P