Alterations in phencyclidine and sigma binding sites in schizophrenic brains Effects of disease process and neuroleptic medication
Alterations in phencyclidine and sigma binding sites in schizophrenic brains Effects of disease process and neuroleptic medication
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DOI：
10.1016/0920-9964(91)90019-n
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发表时间：
1991-12
影响因子：
4.5
通讯作者：
M. Simpson;P. Slater;M. Royston;J. Deakin
中科院分区：
文献类型：
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作者：
M. Simpson;P. Slater;M. Royston;J. Deakin
在对照和精神分裂症死后脑解剖区制备的组织匀浆中，测量了[3H]TCP和[3H](+)3-PPP，分别标记PCP-NMDA和sigma结合位点的放射性配体的特异性结合。[3H]精神分裂症患者眼眶额叶皮层（Brodmann区11）两侧TCP结合增加。这一发现可能是由于眶额叶皮层谷氨酸能神经支配的增加，因为它与我们在该区域增加的[3H]海钠酸盐和[3H]D-天冬氨酸结合的发现相似。相比之下，[3H](+)3-PPP结合在检查的四个脑区中都减少了。在死亡时接受抗精神病药物治疗的精神分裂症患者的大脑减少幅度最大。残留在这些受试者大脑中的神经抑制药可能在体外与[3H](+)3-PPP竞争与sigma位点的结合。
The specific binding of [3H]TCP and [3H](+)3-PPP, radioligands which respectively label PCP-NMDA and sigma binding sites was measured in tissue homogenates prepared from dissected areas of control and schizophrenic postmortem brains. [3H]TCP binding was bilaterally increased in orbital frontal cortex (Brodmann area 11) of schizophrenic brains. This finding may be due to an increased glutamatergic innervation of orbital frontal cortex since it parallels our findings of increased [3H]kainate and [3H]D- aspartate binding in this area. In contrast, [3H](+)3-PPP binding was reduced in each of the four brain regions examined. The reductions were greatest in brains from the schizophrenic subjects receiving neuroleptics at the tine of death. Neuroleptics remaining in the brains of these subjects may compete in vitro with [3H](+)3-PPP for binding to the sigma site.