Control of cell colony growth by contact inhibition
Control of cell colony growth by contact inhibition
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DOI：
10.1038/s41598-020-62913-z
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发表时间：
2018-10
影响因子：
4.6
通讯作者：
S. Schnyder;John J. Molina;R. Yamamoto
中科院分区：
文献类型：
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作者：
S. Schnyder;John J. Molina;R. Yamamoto
接触抑制是一种细胞特性，它限制了细胞在拥挤环境中的迁移和增殖。在这里，我们调查的细胞集落组成的迁移和增殖的细胞在基板上使用最小的模型，结合了运动和增殖的接触抑制的机制的生长动力学。我们发现了两种截然不同的制度。在早期，当接触抑制较弱时，殖民地随时间呈指数增长，完全以增殖速率为特征。在长时间内，殖民地边界以恒定的速度移动，仅由单个细胞的迁移速度决定，而与增殖速率无关。此外，该模型展示了细胞-细胞对齐如何加速菌落生长。我们的模型阐明了简单的局部机械相互作用如何引起接触抑制，以及由此，细胞集落生长如何在局部水平上自组织和控制。
Contact inhibition is a cell property that limits the migration and proliferation of cells in crowded environments. Here we investigate the growth dynamics of a cell colony composed of migrating and proliferating cells on a substrate using a minimal model that incorporates the mechanisms of contact inhibition of locomotion and proliferation. We find two distinct regimes. At early times, when contact inhibition is weak, the colony grows exponentially in time, fully characterised by the proliferation rate. At long times, the colony boundary moves at a constant speed, determined only by the migration speed of a single cell and independent of the proliferation rate. Further, the model demonstrates how cell-cell alignment speeds up colony growth. Our model illuminates how simple local mechanical interactions give rise to contact inhibition, and from this, how cell colony growth is self-organised and controlled on a local level.