Genetic and biological characterization of two novel reassortant H5N6 swine influenza viruses in mice and chickens
Genetic and biological characterization of two novel reassortant H5N6 swine influenza viruses in mice and chickens
复制标题
小鼠和鸡中两种新型重配 H5N6 猪流感病毒的遗传和生物学特征
DOI：
10.1016/j.meegid.2015.08.017
复制
发表时间：
2015-12-01
影响因子：
3.2
通讯作者：
Chen, Hualan
中科院分区：
文献类型：
--
作者：
Li, Xuyong;Fu, Yuguang;Chen, Hualan
Novel H5N6 influenza A viruses have infected birds and human beings and caused four human clinical cases in China since 2014. The pig, as a mixing vessel, plays an important role for influenza virus reassortment and transmission. Towards this, routine surveillance for swine influenza in Guangdong province was conducted in 2014. In this study, we reported the biological characterization of two H5N6 influenza viruses isolated from healthy pigs in Guangdong province. Genetic analysis indicates that the two viruses are reassortants of 2.3.4.4 H5N1 and H6N6 avian influenza viruses with a high similarity to duck and human H5N6 influenza viruses isolated from Guangdong province. The data from chicken and mouse experiments show that the viruses are highly pathogenic in chickens and result in a systemic infection, and replicate in the mouse lung accompanying with a clinical inflammatory pathology. The results of the study demonstrate that the two H5N6 influenza viruses isolated from swine are the avian-originated viruses and have not adapted to swine population yet. However, they might keep evolving and pose a potential risk to public health and the continued surveillance of swine influenza should be strengthened. (C) 2015 Elsevier B.V. All rights reserved.
