Association between serum ficolin-1 level and disease progression in primary biliary cholangitis
Association between serum ficolin-1 level and disease progression in primary biliary cholangitis
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DOI：
10.1371/journal.pone.0238300
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发表时间：
2020-09-11
期刊：
影响因子：
3.7
通讯作者：
Ohira, Hiromasa
中科院分区：
文献类型：
--
作者：
Hayashi, Manabu;Abe, Kazumichi;Ohira, Hiromasa
补体系统中的模式识别分子（PRM）作为补体激活的介体有助于体内平衡。PRM对原发性胆汁性胆管炎（PBC）的作用尚不清楚。在目前的研究中，我们的目的是评估PRM和PBC的临床表现之间的关联。共纳入122例PBC患者和20例健康对照。我们使用储存的血清测量了四种不同的PRM（甘露糖结合凝集素[MBL]、纤维胶凝蛋白-1、纤维胶凝蛋白-2和纤维胶凝蛋白-3），并回顾性分析了PRM与实验室检查结果、组织学检查结果和水肿相关疾病发展之间的相关性。PBC患者中Ficolin-1水平显著高于健康对照组（152 ng/mL vs 102 ng/mL，P = 0.034），但未观察到MBL、Ficolin-2和Ficolin-3水平的显著差异。Ficolin-1与碱性磷酸酶（ALP）呈显著正相关。低纤维胶凝蛋白-1水平与组织学分期和ALP水平无关的水肿相关疾病的发展显著相关（风险比：0.933; 95%置信区间：0.875-0.994; P = 0.032）。纤维胶凝蛋白-1水平较低（< 77 ng/mL）的患者发生糖尿病相关疾病的几率显著增加。在PBC患者中，低纤维胶凝蛋白-1水平与疾病进展相关，与组织学分期和ALP水平无关。
Pattern recognition molecules (PRMs) in the complement system contribute to homeostasis as mediators of complement activation. The contribution of PRMs to primary biliary cholangitis (PBC) is unknown. In the current study, we aimed to assess the association between PRMs and the clinical findings of PBC. A total of 122 PBC patients and 20 healthy controls were enrolled. We measured four different PRMs (mannose-binding lectin [MBL], ficolin-1, ficolin-2 and ficolin-3) using stored sera, and retrospectively analyzed the associations between PRMs and laboratory findings, histological findings, and the development of cirrhosis-related conditions. Ficolin-1 levels were significantly higher in the PBC patients than in the healthy controls (152 ng/mL vs 102 ng/mL, P = 0.034), but no significant differences were observed regarding MBL, ficolin-2, and ficolin-3 levels. Ficolin-1 was significantly correlated with alkaline phosphatase (ALP). Low ficolin-1 levels were significantly associated with the development of cirrhosis-related conditions independent for histological stage and ALP levels (hazard ratio: 0.933; 95% confidence interval: 0.875-0.994; P = 0.032). Patients with low levels of ficolin-1 (< 77 ng/mL) had a significantly increased rate of developing cirrhosis-related conditions. Low ficolin-1 levels were associated with disease progression independent of histological stage and ALP levels in patients with PBC.