Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research.
Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research.
复制标题
干细胞治疗股骨头坏死：从临床应用到相关基础研究
DOI：
10.1186/s13287-018-1018-7
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发表时间：
2018-10-25
影响因子：
7.5
通讯作者：
Peng J
中科院分区：
文献类型：
--
作者：
Li R;Lin QX;Liang XZ;Liu GB;Tang H;Wang Y;Lu SB;Peng J
股骨头坏死（ONFH）是一种与股骨头塌陷相关的难治性疾病，在年轻人群中具有髋关节置换术的风险。因此，越来越多的人关注ONFH的早期干预措施，旨在保留原生关节。干细胞治疗是一种很有前途的治疗方法，最近越来越多的研究都集中在这个话题上。许多临床研究报道了干细胞疗法治疗ONFH的积极结果。为了提高这种方法的治疗效果，也进行了许多相关的基础研究。然而，一些问题必须进一步探讨，如适当的患者选择程序，最佳的干细胞选择方案，理想的注射次数，以及干细胞治疗的安全性。本文就干细胞治疗股骨头坏死的临床研究和基础研究进行综述。
Osteonecrosis of the femoral head (ONFH) is a refractory disease that is associated with collapse of the femoral head, with a risk of hip arthroplasty in younger populations. Thus, there has been an increased focus on early interventions for ONFH that aim to preserve the native articulation. Stem cell therapy is a promising treatment, and an increasing number of recent studies have focused on this topic. Many clinical studies have reported positive outcomes of stem cell therapy for the treatment of ONFH. To improve the therapeutic effects of this approach, many related basic research studies have also been performed. However, some issues must be further explored, such as the appropriate patient selection procedure, the optimal stem cell selection protocol, the ideal injection number, and the safety of stem cell therapy. The purpose of this review is to summarize the available clinical studies and basic research related to stem cell therapy for ONFH.