THE EFFECTS OF FOOD ON DRUG ABSORPTION
THE EFFECTS OF FOOD ON DRUG ABSORPTION
复制标题
食物对药物吸收的影响
DOI：
--
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发表时间：
1996
影响因子：
8.9
通讯作者：
P. Welling
中科院分区：
文献类型：
--
作者：
P. Welling
本章提供了过去五年文献中报告的药物-食物相互作用的最新情况。研究这一现象的研究数量急剧增加，这些研究的许多结果是不可预测和壮观的。药物-食物相互作用应该被认为是配方-食物相互作用，因为越来越多的证据表明，当药物以不同的配方给药时，食物可能会对药物产生不同的影响。药物-食物相互作用可分为五类：导致吸收减少、延迟、增加和加速的药物-食物相互作用，以及食物不起作用的药物-食物相互作用。虽然仍然有必要检查特定药物和药物制剂的药物-食物相互作用，但需要探索其他途径以寻求可能导致更好地预测由于食物存在而引起的循环药物水平变化的性质和程度及其可能的临床影响的机制模式。
This chapter provides an update on drug-food interactions reported in the literature during the past five years. The number of studies examining this phenomenon has increased dramatically, and many of the results of these studies have been unpredictable and spectacular. Drug-food interactions should really be considered as formulation-food interactions because of increasing evidence that a drug may be affected differently by food when it is administered in different formulations. Drug-food interactions may be classified into five categories: those causing reduced, delayed, increased, and accelerated absorption, and those in which food has no effect. While it continues to be necessary to examine drug-food interactions for specific drugs and drug formulations, additional avenues need to be explored to seek mechanistic patterns that may lead to better prediction of the nature and extent of changes in circulating drug levels due to the presense of food, and their possible clinical impact.