The ticking time-bomb of asbestos: its insidious role in the development of malignant mesothelioma.
The ticking time-bomb of asbestos: its insidious role in the development of malignant mesothelioma.
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DOI：
10.1016/j.critrevonc.2012.03.001
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发表时间：
2012-11
期刊：
影响因子：
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通讯作者：
A. Linton;J. Vardy;S. Clarke;N. van Zandwijk
中科院分区：
文献类型：
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作者：
A. Linton;J. Vardy;S. Clarke;N. van Zandwijk
石棉暴露和恶性间皮瘤（MM）之间的关系已经得到很好的建立。尽管越来越多的国家禁止使用石棉，但从暴露到诊断的长期潜伏期以及这些危险纤维的持续存在和使用，导致这种致命疾病在全球范围内的流行率不断上升。虽然在过去50年中，大部分诊断病例涉及职业接触，但很大一部分疾病与非职业、家庭和环境接触有关。在本次审查中，我们将提供有关职业和非职业环境中历史和持续石棉接触影响的最新信息。此外，我们将解决围绕使用温石棉，性别和遗传对这种疾病的发展，儿童间皮瘤和共同病因因素，包括SV40暴露的影响尚未解决的争议。
The relationship between asbestos exposure and malignant mesothelioma (MM) has been well established. Despite bans on asbestos use in an increasing number of nations, the prolonged latency from exposure to diagnosis, and the ongoing presence and use of these dangerous fibres, have led to the increasing prevalence of this deadly disease worldwide. Whilst occupational contact has been implicated in the bulk of diagnosed cases over the past 50 years, a significant proportion of disease has been linked to para-occupational, domestic and environmental exposure. In this review, we will provide an update on the impact of historical and ongoing asbestos contact in both occupational and non-occupational settings. Furthermore, we will address the unresolved controversies surrounding the use of chrysotile asbestos, the effect of gender and genetics on development of this disease, childhood mesothelioma and co-aetiological factors including SV40 exposure.