Hypoventilation Syndromes
Hypoventilation Syndromes
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DOI：
10.1016/j.mcna.2011.09.002
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发表时间：
2011-11-01
影响因子：
5.9
通讯作者：
Jones, Shirley F.
中科院分区：
文献类型：
--
作者：
Chebbo, Ahmad;Tfaili, Amer;Jones, Shirley F.
换气不足综合征代表了影响中枢呼吸控制、呼吸力学或两者的各种疾病。肥胖低通气综合征是一种临床上重要的疾病，如果没有被认识到，会导致严重的心血管和代谢后果。哮喘和COPD的通气不足是由气流阻塞和死腔增加引起的机械挑战引起的。在神经肌肉疾病中，呼吸肌无力导致通气不足。胸腔容积减少和胸部扩张受限突出了与胸壁疾病相关的通气不足中所见的限制性呼吸功能障碍。尽管机制，有效的低通气治疗的目标是潜在的疾病和使用无创通气。
The hypoventilation syndromes represent a variety of disorders that affect central ventilatory control, respiratory mechanics, or both. Obesity hypoventilation syndrome is a clinically important disorder with serious cardiovascular and metabolic consequences if unrecognized. Hypoventilation in asthma and COPD is caused by mechanical challenges imparted by airflow obstruction and increase in dead space. In neuromuscular disease, respiratory muscle weakness results in hypoventilation. Decreases in thoracic volume and limited expansion of the chest highlight the restrictive ventilatory impairments seen in hypoventilation associated with chest wall disorders. Despite the mechanism, effective hypoventilation treatment targets the underlying disease and use of noninvasive ventilation.