Comparative study of pregnancy outcomes between day 3 embryo transfer and day 5 blastocyst transfer in patients with progesterone elevation
Comparative study of pregnancy outcomes between day 3 embryo transfer and day 5 blastocyst transfer in patients with progesterone elevation
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DOI：
10.1177/0300060513489480
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发表时间：
2013-08-01
影响因子：
1.6
通讯作者：
Chen, Fan
中科院分区：
文献类型：
--
作者：
Li, Rui-Rui;Dong, Yue-Zhi;Chen, Fan
目的探讨孕激素（P）水平升高对第3天胚胎和第5天囊胚移植妊娠结局的影响。根据人绒毛膜促性腺激素（hCG）注射当天血清P水平，将第3天胚胎和第5天囊胚移植周期分为正常P水平组（P <1.5ng/ml）和升高P水平组（P>1.5ng/ml）。在第3天胚胎移植周期（n=2345）中，P水平正常组的临床妊娠率明显高于P升高组（分别为55.4%和46.7%），P水平正常组的异位妊娠率明显低于P升高组（分别为2.8%和7.9%）。在第5天的囊胚移植周期（n=523），有两组之间的临床妊娠率和异位妊娠率无显着差异，根据P level. Conclusions这些初步研究结果表明，第5天囊胚移植应采用P升高的hCG给药日的患者。
Objective To explore the effects of progesterone (P) elevation on pregnancy outcomes of day 3 embryo and day 5 blastocyst transfer.Methods Clinical outcomes (pregnancy and ectopic pregnancy rates) following day 3 embryo and day 5 blastocyst transfer cycles were retrospectively analysed. Day 3 embryo and day 5 blastocyst transfer cycles were divided into normal P level (P1.5ng/ml) and P elevation group (P>1.5ng/ml), based on the serum P level on the day of human chorionic gonadotropin (hCG) administration.Results A total of 2868 cycles were analysed. In day 3 embryo transfer cycles (n=2345), the clinical pregnancy rate was significantly higher in the normal P level group compared with the P elevation group (55.4% versus 46.7%, respectively) and the ectopic pregnancy rate was significantly lower in the normal P level group compared with the P elevation group (2.8% versus 7.9%, respectively). In day 5 blastocyst transfer cycles (n=523), there were no significant differences in the clinical pregnancy and ectopic pregnancy rates between the two groups, based on the P level.Conclusion These preliminary findings suggest that day 5 blastocyst transfer should be adopted for patients with P elevation on the day of hCG administration.