Expression of E-cadherin, vimentin and beta-catenin in ameloblastoma and association with clinicopathological characteristics of ameloblastoma.
Expression of E-cadherin, vimentin and beta-catenin in ameloblastoma and association with clinicopathological characteristics of ameloblastoma.
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E-钙粘蛋白、波形蛋白和β-连环蛋白在成釉细胞瘤中的表达及其与成釉细胞瘤临床病理特征的关系。
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Jingdong Liu
中科院分区：
文献类型：
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作者：
Fengyu Hao;Jie Liu;Ming Zhong;Junting Wang;Jingdong Liu
目的：成釉细胞瘤呈侵袭性生长，易复发。本研究检测E-钙粘附素、波形蛋白和β-连接素在造釉细胞瘤中的表达，探讨其与成釉细胞瘤临床病理特征的关系。方法：采用免疫组织化学方法检测E-钙粘附素、波形蛋白和β-连接素在成釉细胞瘤中的表达，并进一步探讨其与造釉细胞瘤临床病理特征的关系。结果：成釉细胞瘤外周、柱状和立方上皮细胞膜上E-钙粘附素表达减少或缺失，Vimentin在间质和成釉细胞瘤上皮细胞中高表达，与Vimentin表达呈负相关。成釉细胞瘤上皮细胞膜上β-连环蛋白表达减少，但在胞浆和/或胞核可见异位表达。结论：E-钙粘附素、β-连环蛋白和波形蛋白参与了成釉细胞瘤的发生、发展，可作为成釉细胞瘤侵袭性的生物标志物。
Objective: Ameloblastoma shows invasive growth and is susceptible to recurrence. This study aimed to.detect the expression of E-Cadherin, Vimentin and β-Catenin (proteins related to epithelial mesenchymal transformation.(EMT) in the ameloblastoma and to explore association with clinicopathological characteristics of ameloblastoma..Methods: Immunohistochemistry was employed to detect the protein expression of E-Cadherin, Vimentin.and β-Catenin in the ameloblastoma, and its association with clinicopathological characteristics of ameloblastoma.was further evaluated. Results: E-Cadherin expression was reduced or absent on the membrane of the peripheral.columnar and cubic epithelial cells; Vimentin expression was high in the interstitium as well as epithelial cells in.ameloblastoma; E-Cadherin expression was negatively related to Vimentin expression. β-catenin expression on the.membrane of ameloblastoma epithelial cells reduced, but its ectopic expression was observed in the cytoplasm.and/or nucleus. Conclusion: EMT related proteins E-Cadherin, β-catenin and Vimentin are involved in the occurrence.and development of ameloblastoma and these proteins can be used as biomarkers of invasiveness of ameloblastoma..