Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the Chromosomes and Morphology (CHAMP) Collaborative Study Group.
Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the Chromosomes and Morphology (CHAMP) Collaborative Study Group.
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1996-02
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通讯作者：
C. Fletcher;Måns Åkerman;P. D. Cin;I. Wever;N. Mandahl;F. Mertens;F. Mitelman;J. Rosai;A. Rydholm;R. Sciot;G. Tallini;H. Berghe;W. D. V. Ven;R. Vanni;H. Willén
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作者：
C. Fletcher;Måns Åkerman;P. D. Cin;I. Wever;N. Mandahl;F. Mertens;F. Mitelman;J. Rosai;A. Rydholm;R. Sciot;G. Tallini;H. Berghe;W. D. V. Ven;R. Vanni;H. Willén
软组织肿瘤通常表现出细胞遗传学异常，其中一些是肿瘤特异性的。脂肪瘤是软组织肿瘤中最大的一类，并且已经鉴定出许多核型畸变。然而，明确的形态学和核型之间的相关性还没有进行系统的基础上，在双盲设置。在不了解临床资料的情况下，对178例脂肪瘤性肿瘤的形态学特征和组织学诊断进行了独立回顾。然后将一致的诊断与临床发现相关联，并使用短期培养的G显带制备物与肿瘤的核型进行比较。这些数据由病理学家、遗传学家和外科医生组成的多中心协作组整理。克隆性染色体异常被确定在149例研究（84%），在很大程度上，核型与形态学诊断。具体地说，27例粘液样脂肪肉瘤及其低分化变体中有26例（96%）显示t（12;16）; 37例非典型脂肪瘤中有29例（78%）93例皮下和肌内脂肪瘤中74例（80%）有核型异常，主要累及12 q、6p和13 q; 8例梭形细胞和多形性脂肪瘤中7例16 q畸变，3例脂肪母细胞瘤8 q重排，2例冬眠瘤11 q异常。我们的结论是，细胞遗传学异常是常见的脂肪瘤，在许多情况下可靠的形态亚型相关，并可以在组织学边缘或困难的情况下诊断价值。
Soft tissue tumors commonly show cytogenetic abnormalities, some of which are tumor specific. Lipomatous tumors represent the largest category of soft tissue neoplasms, and numerous karyotypic aberrations have been identified. However, clear-cut correlation between morphology and karyotype has not been undertaken on a systematic basis in a double-blind setting. The morphological features and histological diagnosis of 178 lipomatous neoplasms were reviewed independently without knowledge of the clinical data. The consensus diagnoses were then correlated with the clinical findings and compared with the tumors' karyotypes, using G-banded preparations from short-term cultures. The data were collated by a multicenter collaborative group of pathologists, geneticists, and surgeons. Clonal chromosomal abnormalities were identified in 149 cases studied (84%) and, to a large extent, the karyotype correlated with the morphological diagnosis. Specifically, 26 (96%) of 27 myxoid liposarcomas and its poorly differentiated variants showed a t(12;16); 29 (78%) of 37 atypical lipomatous tumors (including 5 dedifferentiated cases) showed ring chromosomes; 74 (80%) of 93 subcutaneous and intramuscular lipomas had karyotypic aberrations affecting mainly 12q, 6p, and 13q; 7 of 8 spindle cell and pleomorphic lipomas had aberrations of 16q; 3 lipoblastomas showed 8q rearrangements; and 2 hibernomas showed 11q abnormalities. We conclude that cytogenetic abnormalities are common in lipomatous tumors, correlate reliably with morphological sub-type in many cases, and can be of diagnostic value in histologically borderline or difficult cases.