Non-excitable fluorescent protein orthologs found in ctenophores.
Non-excitable fluorescent protein orthologs found in ctenophores.
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DOI：
10.1186/s12862-016-0738-5
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发表时间：
2016-08-24
影响因子：
3.4
通讯作者：
D Haddock SH
中科院分区：
文献类型：
--
作者：
Francis WR;Christianson LM;Powers ML;Schnitzler CE;D Haddock SH
荧光蛋白是在后生动物的许多分支中发现的具有光学活性的蛋白质。最近在栉水母中发现了一种荧光蛋白，但这被认为是来自刺胞动物，再次提出了这组蛋白质起源的问题。通过分析来自30个栉水母的转录组数据，我们在每个栉水母中以及在leidyi记忆水母的基因组中发现了一个与荧光蛋白相似的同源蛋白群的成员。这些同源物缺乏参与发色团形成的规范残基，表明了另一种功能。栉水母蛋白家族在荧光蛋白中的系统发育位置表明，该基因存在于所有栉水母的共同祖先中，并且先前在栉水母中发现的荧光蛋白实际上来自虹吸水母。本文的在线版本（doi:10.1186/s12862-016-0738-5）包含补充材料，可供授权用户使用。
Fluorescent proteins are optically active proteins found across many clades in metazoans. A fluorescent protein was recently identified in a ctenophore, but this has been suggested to derive from a cnidarian, raising again the question of origins of this group of proteins. Through analysis of transcriptome data from 30 ctenophores, we identified a member of an orthologous group of proteins similar to fluorescent proteins in each of them, as well as in the genome of Mnemiopsis leidyi. These orthologs lack canonical residues involved in chromophore formation, suggesting another function. The phylogenetic position of the ctenophore protein family among fluorescent proteins suggests that this gene was present in the common ancestor of all ctenophores and that the fluorescent protein previously found in a ctenophore actually derives from a siphonophore. The online version of this article (doi:10.1186/s12862-016-0738-5) contains supplementary material, which is available to authorized users.