MOMENT ANALYSIS OF MULTIBREATH LUNG WASHOUT
MOMENT ANALYSIS OF MULTIBREATH LUNG WASHOUT
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DOI：
10.1152/jappl.1975.38.2.328
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发表时间：
1975-01-01
影响因子：
3.3
通讯作者：
CHESTER, EH
中科院分区：
文献类型：
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作者：
SAIDEL, GM;SALMON, RB;CHESTER, EH
多呼吸氮冲洗的力矩分析已经开发，以提供一个敏感的，定量的措施，表征肺通气的不均匀性。为了验证分析方案，我们研究了5名正常受试者和16名阻塞性肺病患者，他们在恒定的潮汐量和频率下进行了每次冲洗试验。受试者以不同潮气量（0.5-1.5升）和不同频率（10-30次/min）进行3-4次失水试验。将冲刷数据绘制为无因次潮末氮浓度与由功能剩余容量（CEV/FRC）归一化的累积过期体积的关系，使得每个个体的冲刷曲线几乎可以重叠，尽管每次测试的呼吸频率和潮气量都发生了变化。无因次冲刷曲线被视为一个分布，从中得到归一化一阶矩（M1/Mo）和二阶矩（M2/Mo）。这些参数清楚地显示了各种疾病状态的诊断聚类。与正常人相比，哮喘患者M1/Mo值高26%，支气管炎患者高38%，肺气肿患者高52%。这一刻的分析提供了一个客观的，定量的评估通风不均匀的程度没有肺模型的规格
A moment analysis of multibreath nitrogen washout has been developed to provide a sensitive, quantitative measure that characterizes the inhomogeneity of pulmonary ventilation. To test the analysis scheme, we studied 5 normal subjects and 16 subjects with obstructive lung disease who performed each washout test at constant tidal volume and frequency. Subjects executed the wahout test 3–4 times at different tidal volumes (0.5–1.5 liters) and frequencies (10–30/min). Plotting washout data as dimensionless end-tidal nitrogen concentration versus the cumulative expired volume normalized by the functional residual capacity (CEV/FRC) renders the washout curves of each individual almost superposab le despite changes in breathing frequency and tidal volume from test to test. The dimensionless washout curve is treated as a distribution from which the normalized first (M1/Mo) and second (M2/Mo) moments are obtained. These parameters clearly display diagnostic clustering for various disease states. With respect to the normal subjects, the magnitude of M1/Mo was 26% greater for asthmatics, 38% greater for bronchitics, and 52% greater for emphysematics. This moment analysis provides an objective, quantitative assessment of the extent of ventilation inhomogeneities without specification of a lung model