Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig
Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig
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DOI：
10.1016/s0378-5955(02)00345-3
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发表时间：
2002-05-01
期刊：
影响因子：
2.8
通讯作者：
Yamashita, T
中科院分区：
文献类型：
--
作者：
Himeno, C;Komeda, M;Yamashita, T
本研究通过微导管渗透泵给药系统，证实了地塞米松(Dex)耳蜗液对氨基糖苷类药物耳毒性的减轻作用。结果表明，地塞米松治疗耳蜗卡那霉素前后对耳毒性的预防效果优于仅在卡那霉素治疗后使用地塞米松治疗。浓度为1 ng/ml的地塞米松对卡那霉素诱发的听性脑干反应阈值漂移和外毛细胞存活均有最大的保护作用。这些结果表明，地塞米松治疗减轻了氨基糖苷类毒性对内耳的功能和结构的损害。(C)2002 Elsevier Science B.V.保留所有权利。
This study demonstrates the attenuation of aminoglycoside ototoxicity by cochlear infusion of dexamethasone (Dex) using a microcannulation-osmotic pump delivery system. The results indicate that treating the cochlea with Dex both before and after kanamycin administration was more effective in preventing ototoxicity than Dex treatment only after kanamycin administration. A concentration of 1 ng/ml Dex showed the greatest protective effect on both kanamycin-induced threshold shift of the auditory brainstem response and outer hair cell survival. These results show that the Dex treatment attenuates both functional and structural damage of the inner ear from aminoglycoside toxicity. (C) 2002 Elsevier Science B.V. All rights reserved.