Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population
Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population
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DOI：
10.1007/s00702-006-0436-3
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发表时间：
2006-10-01
影响因子：
3.3
通讯作者：
Saitoh, O.
中科院分区：
文献类型：
--
作者：
Kunugi, H.;Hashimoto, R.;Saitoh, O.
我们首次研究了精神分裂症与间变性淋巴瘤激酶（ALK）基因之间的可能联系，该基因在神经发育中起着重要作用。当检测两个非同义多态性（Arg1491Lys和Glu1529Asp）时，患者和对照组的基因型和等位基因分布存在显著差异。小等位基因（1491Lys-1529Asp）的纯合个体在患者中比在对照组中更常见（p = 0.0064，优势比2.4,95% CI 1.3-4.6）。这些结果表明，ALK基因的遗传变异可能与精神分裂症的易感性有关。
We examined, for the first time, the possible association between schizophrenia and the anaplastic lymphoma kinase (ALK) gene which plays an important role in neurodevelopment. When two nonsynonymous polymorphisms (Arg1491Lys and Glu1529Asp) were examined, there were significant differences in genotype and allele distributions between patients and controls. Individuals homozygous for the minor allele (1491Lys-1529Asp) were more common in patients than in controls (p = 0.0064, odds ratio 2.4, 95% CI 1.3-4.6). These results suggest that genetic variations of the ALK gene might confer susceptibility to schizophrenia.