Study of Serum Levels of Leptin, C-Reactive Protein and Nutritional Status in Hemodialysis Patients.
Study of Serum Levels of Leptin, C-Reactive Protein and Nutritional Status in Hemodialysis Patients.
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DOI：
10.5812/ircmj.26880
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发表时间：
2015-08
影响因子：
0.4
通讯作者：
Pourmofatteh M
中科院分区：
文献类型：
--
作者：
Montazerifar F;Karajibani M;Hassanpour Z;Pourmofatteh M
瘦素由脂肪组织分泌，会降低食欲。然而，瘦素在血液透析（HD）相关营养不良发病机制中的作用尚未得到充分评估。该研究的目的是调查血液透析患者的血清瘦素水平、血清C反应蛋白（CRP）水平和营养状况之间的关联。这项分析描述性研究包括 45 名血液透析患者和 40 名健康受试者。测量生化参数和血清瘦素水平。使用食物频率问卷（FFQ）和体重指数（BMI）的计算来评估营养状况。 HD患者血清瘦素（P < 0.05）和白蛋白（P < 0.0001）水平以及BMI（P < 0.001）显着低于对照组（P < 0.0001），而CRP水平显着高于对照组（P < 0.0001）。与对照组相比，HD 患者每天消耗的食物组份量较低 (P < 0.0001)。血清瘦素和白蛋白水平与 BMI 之间存在显着的正相关关系。瘦素水平、CRP 水平和其他变量之间没有发现显着相关性。研究结果表明，瘦素水平低可能是 HD 患者营养不良的一个促成因素。需要进一步的研究来确定瘦素水平与血液透析患者营养因素之间的关系的重要性。
Leptin is secreted by adipose tissue and decreases appetite. However, the role of leptin in the pathogenesis of hemodialysis (HD)-related malnutrition has not been fully evaluated. The aim of study was to investigate the association between the serum leptin levels, serum C-reactive protein (CRP) levels, and nutritional status in hemodialysis patients. This analytical descriptive study included 45 hemodialysis patients and 40 healthy subjects. Biochemical parameters and serum leptin levels were measured. The nutritional status was evaluated using a food frequency questionnaire (FFQ) and the calculation of the body mass index (BMI). Serum leptin (P < 0.05) and albumin (P < 0.0001) levels and BMI (P < 0.001) of HD patients were significantly lower, while CRP levels were significantly higher than those of controls (P < 0.0001). HD patients consumed the lower daily servings of the food groups compared to the control subjects (P < 0.0001). A significant positive correlation between serum levels of leptin and albumin and BMI was demonstrated. No significant correlations were identified between leptin level, CRP level, and other variables. The findings suggest that low levels of leptin may be a contributory factor for malnutrition in HD patients. Further studies are required to ascertain the significance of leptin levels in relation to nutritional factors in hemodialysis patients.