SERUM VITAMIN-A IN PREMATURE AND TERM NEONATES
SERUM VITAMIN-A IN PREMATURE AND TERM NEONATES
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DOI：
10.1016/s0022-3476(78)80086-9
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发表时间：
1978-01-01
影响因子：
5.1
通讯作者：
EHRLICH, FE
中科院分区：
文献类型：
--
作者：
BRANDT, RB;MUELLER, DG;EHRLICH, FE
用荧光分光光度法测定早产儿和足月新生儿血清维生素A。早产新生儿（N = 42;胎龄= 32 . ±. 0.4 wk）的血清维生素A水平（14.9 ± 0.001）。0.98μ g/dl）显著低于（P < 0.001）足月新生儿（N = 51; 22.4 ±. 0.99μ g/dl）。36周胎龄婴儿的维生素A平均血清值与足月新生儿的维生素A平均血清值无统计学差异。血清维生素A值与胎龄的线性回归分析显示无显著相关性。血清维生素A和血清蛋白浓度之间存在线性相关（P < 0.05），可能表明视黄醇结合蛋白浓度较低。由于维生素A参与促进粘液分泌细胞，早产儿可能比足月儿更容易患涉及粘膜上皮的疾病，包括坏死性小肠结肠炎。
Serum vitamin A was determined in premature and term neonates by a specific spectrofluorometric method. Premature neonates (N = 42; gestational age = 32 .+-. 0.4 wk) had a serum vitamin A level (14.9 .+-. 0.98 .mu.g/dl) significantly lower (P < 0.001) than that of term neonates (N = 51; 22.4 .+-. 0.99 .mu.g/dl). The vitamin A mean serum values of infants of 36 wk gestational age were not statistically different from those of the term neonates. Linear regression analysis for serum vitamin A values vs. gestational age showed no significant correlation. A linear correlation (P < 0.05) was found between serum vitamin A and serum protein concentrations, perhaps indicative of a lower concentration of retinol-binding protein. Since vitamin A is involved in the promotion of mucous-secreting cells, the premature neonate may be at greater risk than the term infant for diseases involving the mucosal epithelium, including necrotizing enterocolitis.