Aortic Plaque Distribution, and Association between Aortic Plaque and Atherosclerotic Risk Factors: An Aortic Angioscopy Study
Aortic Plaque Distribution, and Association between Aortic Plaque and Atherosclerotic Risk Factors: An Aortic Angioscopy Study
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DOI：
10.5551/jat.48181
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发表时间：
2019-01-01
影响因子：
4.4
通讯作者：
Takahashi, Atsushi
中科院分区：
文献类型：
--
作者：
Kojima, Keisuke;Kimura, Shigeki;Takahashi, Atsushi
目的：体内主动脉亚临床斑块形态和斑块分布的知识尚不清楚。本研究的目的是增加身体的知识，在这方面的area.Methods：我们连续37例稳定型心绞痛患者接受非梗阻性血管镜检查的冠状动脉和主动脉后立即经皮冠状动脉介入治疗。我们评估了主动脉斑块的存在和斑块不稳定性的分布。根据全主动脉易损斑块的数量将患者分为低[0-11]和高[>= 12]组。我们评估了两组患者在心血管危险因素方面的关系。结果：所有患者的主动脉斑块均通过非阻塞性血管镜检查发现，肾下腹主动脉（IAA）斑块数量最多主动脉弓、降胸主动脉、肾上腹主动脉、髂内动脉和髂总动脉分别为65%、76%、65%、95%和49%; p< 0.001）。IAA组的最大黄色等级、强烈黄色斑块、破裂斑块和血栓的数量最高（p< 0.001）。高易损斑块组糖尿病和外周动脉疾病的患病率较高（分别为83.3%与40.0%，=0.010，50.0%与8.0%，p-0.005）。结论：主动脉粥样硬化在IAA时最严重，稳定型心绞痛患者主动脉斑块易损性及分布与糖尿病和外周动脉病变的患病率相关。非阻塞性血管镜检查可以识别未来主动脉事件高风险的患者。
Aim: Knowledge of subclinical plaque morphology and plaque distribution in the aorta in vivo remains unclear. This study aimed to increase the body of knowledge in this area.Methods: We enrolled 37 consecutive patients with stable angina pectoris patients who underwent nonobstructive angioscopy for both the coronary artery and aorta immediately after percutaneous coronary intervention. We evaluated the presence of aortic plaques and the distribution of plaque instability. Patients were allocated into two groups according to the number of vulnerable plaques in whole aorta (a low [0-11] and high [>= 12] group). We evaluated the relationships between the two groups in terms of cardiovascular risk factors.Results: Aortic plaques were identified using non-obstructive angioscopy in all patients, and the greatest number of plaques was found at the infrarenal abdominal aorta (IAA) (the aortic arch, the descending thoracic aorta, the suprarenal abdominal aorta, the IAA, and common iliac artery; 65%, 76%, 65%, 95%, and 49%, respectively; p< 0.001). The maximum yellow grade, and the number of intense yellow plaques, ruptured plaques, and thrombi were highest at the IAA (p< 0.001). The prevalence of diabetes mellitus and peripheral arterial disease was higher in the high vulnerable plaque group (83.3% vs. 40.0%, =0.010, 50.0% vs. 8.0%, p-0.005, respectively).Conclusions: Aortic atherosclerosis was the most severe at the IAA, and aortic plaque vulnerability and distribution were associated with the prevalence of diabetes mellitus and peripheral artery disease in patients with stable angina pectoris. Non-obstructive angioscopy may identify patients at high risk of future aortic events.