Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice.
Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice.
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DOI：
10.1093/gerona/55.1.b5
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
Ting‐Ting Huang;E. Carlson;A. Gillespie;Yuping Shi;Charles J. Epstein
中科院分区：
文献类型：
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作者：
Ting‐Ting Huang;E. Carlson;A. Gillespie;Yuping Shi;Charles J. Epstein
氧化损伤与衰老过程和许多退行性疾病有关。为了研究氧自由基在哺乳动物衰老过程中的作用，我们测定了CD-1背景下表达CuZn超氧化物歧化酶（CuZnSOD）水平升高的转基因小鼠的寿命，CuZnSOD是代谢超氧化物自由基的酶。纯合子转基因小鼠各组织CuZnSOD水平升高2 ~ 5倍时，其寿命略有降低，半合子转基因小鼠各组织CuZnSOD水平升高15 ~ 3倍时，其寿命与非转基因小鼠无显著差异。结果表明，CuZnSOD的组成和普遍过表达并不足以延长转基因小鼠的寿命。
Oxidative damage has been implicated in the aging process and in a number of degenerative diseases. To investigate the role of oxygen radicals in the aging process in mammals, the life spans of transgenic mice on a CD-1 background expressing increased levels of CuZn superoxide dismutase (CuZnSOD), the enzyme that metabolizes superoxide radicals, were determined. Homozygous transgenic mice with a two- to five-fold elevation of CuZnSOD in various tissues showed a slight reduction of life span, whereas hemizygous mice with a 15- to 3-fold increase of CuZnSOD showed no difference in life span from that of the nontransgenic littermate controls. The results suggest that constitutive and ubiquitous overexpression of CuZnSOD alone is not sufficient to extend the life spans of transgenic mice.