Annexin 1: a paracrine/juxtacrine mediator of glucorticoid in the action in the neuroendocrine system
Annexin 1: a paracrine/juxtacrine mediator of glucorticoid in the action in the neuroendocrine system
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DOI：
10.1002/cbf.1076
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发表时间：
2003-09-01
影响因子：
3.6
通讯作者：
Morris, J
中科院分区：
文献类型：
--
作者：
Buckingham, JC;Solito, E;Morris, J
糖皮质激素(GCs)在维持体内平衡方面起着重要作用。在正常情况下，它们的分泌受到复杂的伺服机制的严格调控，类固醇通过抑制ACTH及其下丘脑释放因子(CRH和AVP)的合成和释放，从而减少对肾上腺皮质的正向驱动。GC对激素释放的反馈作用迅速发展(在几分钟内)，远远早于激素合成的任何明显变化。通过体内和体外模型的免疫中和、基因打靶和药理学策略，我们已经确定Annexin 1是一种钙和磷脂结合蛋白，是GCs早期抑制多肽释放的关键介质。这篇简短的综述概述了这项工作，并描述了分子和细胞研究，这些研究为神经内分泌系统中依赖膜联蛋白I的GC信号转导机制提供了洞察力。版权所有(C)2003 John Wiley Sons，Ltd.
Glucocorticoids (GCs) play an essential role in the maintenance of homeostasis. In normal circumstances their secretion is tightly regulated by a complex servo mechanism through which the steroids suppress the synthesis and release of ACTH and its hypothalamic releasing factors (CRH and AVP) and thereby reduce the positive drive to the adrenal cortex. The feedback actions of GCs on hormone release develop rapidly (within minutes), well before any changes in hormone synthesis are apparent. By using immunoneutralization, gene targeting and pharmacological strategies in in vivo and in vitro models, we have identified annexin 1, a Ca2+- and phospholipid-binding protein, as a key mediator of the early inhibitory actions of GCs on peptide release. This brief review outlines this work and describes molecular and cellular studies which have provided insight into the mechanism of annexin I-dependent GC signalling in the neuroendocrine system. Copyright (C) 2003 John Wiley Sons, Ltd.