Auditory thalamus integrates visual inputs into behavioral gains
Auditory thalamus integrates visual inputs into behavioral gains
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DOI：
10.1038/nn1528
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发表时间：
2005-09-01
影响因子：
25
通讯作者：
Ono, T
中科院分区：
文献类型：
--
作者：
Komura, Y;Tamura, R;Ono, T
通过结合多感官信号，我们获得了强大的感知，并对周围环境做出了更正确、更快速的反应。大脑是如何以及在哪里将跨模态感觉信息联系起来，从而产生这种行为优势的？感觉丘脑的经典作用是将特定模式的信息传递给皮层。在这里，我们发现，在大鼠的丘脑中，视觉线索影响听觉反应，听觉反应有两个不同的组成部分：一个是早期阶段的，然后是后期逐渐积累的，在奖励之前达到顶峰。虽然双峰呈现和奖励值对行为表现的影响相似，但跨模态对神经活动的影响表现出独特的时间动态：它影响早期分量的振幅和晚期分量的起始水平，而奖励值仅影响晚期分量的斜率。这些结果表明，交叉模态线索调节感觉丘脑的增益，可能对最佳行为的选择提供启动影响。
By binding multisensory signals, we get robust percepts and respond to our surroundings more correctly and quickly. How and where does the brain link cross-modal sensory information to produce such behavioral advantages? The classical role of sensory thalamus is to relay modality-specific information to the cortex. Here we find that, in the rat thalamus, visual cues influence auditory responses, which have two distinct components: an early phasic one followed by a late gradual buildup that peaks before reward. Although both bimodal presentation and reward value had similar effects on behavioral performance, the cross-modal effect on neural activity showed unique temporal dynamics: it affected the amplitude of the early component and starting level of the late component, whereas reward value affected only the slope of the late component. These results demonstrate that cross-modal cueing modulates gain in the sensory thalamus, potentially providing a priming influence on the choice of an optimal behavior.