Polymeric endoaortic paving: Mechanical, thermoforming, and degradation properties of polycaprolactone/polyurethane blends for cardiovascular applications
Polymeric endoaortic paving: Mechanical, thermoforming, and degradation properties of polycaprolactone/polyurethane blends for cardiovascular applications
复制标题
DOI：
10.1016/j.actbio.2010.09.004
复制
发表时间：
2011-01-01
影响因子：
9.7
通讯作者：
Vande Geest, J. P.
中科院分区：
文献类型：
--
作者：
Ashton, J. H.;Mertz, J. A. M.;Vande Geest, J. P.
聚合物主动脉内膜铺装（PEAP）是一种将聚合物在血管内输送并热成型以覆盖或“铺装”主动脉腔的过程。该方法可以改进传统的主动脉内腔治疗，允许适形移植物应用，降低内漏风险，并根据复杂的患者几何形状定制。通过对不同配比的聚己内酯(PCL)/聚氨酯（PU）共混物的力学性能、热成型性能和降解性能的表征，对其作为PEAP的潜在材料进行了评价。双轴拉伸试验表明，共混物的刚度与主动脉组织相似，PCL含量越高，共混物的刚度越高，并可能受到热成型和降解的影响。在较高的PCL含量和较高的加热温度下，热成型后的共混管能保持较高的管径增长；50/50混合管加热到55摄氏度，能够保持90%的直径增加。共混物的分层力范围为41 ~ 235 nm（-2）。在假单胞菌脂肪酶溶液中，50/50混合物的降解率比纯PCL低94%，10/90混合物无降解。这些结果表明，由PCL/PU混合物组成的REAP可能有助于开发下一代主动脉内治疗。(C) 2010 Acts materials Inc。Elsevier Ltd.出版。版权所有。
Polymeric endoaortic paving (PEAP) is a process by which a polymer is endovascularly delivered and thermoformed to coat or "pave" the lumen of the aorta. This method may offer an improvement to conventional endoaortic therapy in allowing conformal graft application with reduced risk of endoleak and customization to complex patient geometries. Polycaprolactone (PCL)/polyurethane (PU) blends of various blend ratios were assessed as a potential material for PEAP by characterizing their mechanical, thermoforming and degradation properties. Biaxial tension testing revealed that the blends' stiffness is similar to that of aortic tissue, is higher for blends with more PCL content, and may be affected by thermoforming and degradation. Tubes of blends were able to maintain a higher diameter increase after thermoforming at higher PCL content and higher heating temperatures; 50/50 blend tubes heated to 55 degrees C were able to maintain 90% of the diameter increase applied. Delamination forces of the blends ranged from 41 to 235 N m(-2). In a Pseudomonas lipase solution, the 50/50 blend had a 94% lower degradation rate than pure PCL, and the 10/90 blend exhibited no degradation. These results indicate that REAP, consisting of a PCL/PU blend, may be useful in developing the next generation of endoaortic therapy. (C) 2010 Acts Materialia Inc. Published by Elsevier Ltd. All rights reserved.