Microbial causes of neonatal conjunctivitis.
Microbial causes of neonatal conjunctivitis.
复制标题
新生儿结膜炎的微生物原因。
DOI：
10.1016/s0022-3476(84)80287-5
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Smith,AL
中科院分区：
文献类型：
--
作者：
Sandström,KI;Bell,TA;Chandler,JW;Kuo,CC;Wang,SP;Grayston,JT;Foy,HM;Stamm,WE;Cooney,MK;Smith,AL
我们通过比较55名化脓性结膜炎婴儿和60名健康对照婴儿，评估了新生儿结膜炎的微生物病因。在30例未经治疗的患者中，77%的患者从炎症更严重的眼睛获得的革兰氏染色涂片中观察到平均每1000×显微镜视野中>5个白细胞，而57例对照中没有。从未治疗患者中分离出的病原体多于对照组，包括嗜血杆菌属。(17%对2%，P=0.01）。金黄色葡萄球菌（17% vs 2%，P=0.01）。沙眼衣原体（14% vs 0%，P=0.01）、肠球菌（8% vs 0%，P=0.05）和肺炎链球菌（11% vs 2%，P=0.06）。58%的患者和5%的对照组结膜分离出一种或多种病原体（P<0.001）。涂片上观察到的细菌形态与培养的病原体相关。嗜血杆菌属的分离或s肺炎与泪管狭窄相关。我们的结论是，几种微生物病原体牵连在新生儿结膜炎。这些微生物对抗菌剂的敏感性不同，因此需要进行培养和敏感性测试作为治疗指南。
We assessed the microbial causes of neonatal conjunctivitis by comparing 55 infants with purulent conjunctivitis and 60 healthy control infants. A mean of >5 leukocytes per 1000× microscopic field was seen in Gram-stained smears obtained from the more inflamed eye in 77% of 30 untreated patients but none of 57 controls. Pathogens isolated more often from untreated patients than from controls included Haemophilus spp. (17% vs 2%, P=0.01). Staphylococcus aureus (17% vs 2%, P=0.01). Chlamydia trachomatis (14% vs 0%, P=0.01), enterococci (8% vs 0%, P=0.05), and Streptococcus pneumoniae (11% vs 2%, P=0.06). One or more of these pathogens were isolated from the conjunctivae in 58% of patients and 5% of controls (P<0.001). Bacterial morphology seen on smear correlated with the pathogens cultured. Isolation of Haemophilus spp. or S. pneumoniae was associated with dacryostenosis. We conclude that several microbial pathogens are implicated in neonatal conjunctivitis. These organisms have differing susceptibilities to antimicrobial agents, so culture and sensitivity testing are required as a guide to therapy.